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COL1A2 — SMAD3

Text-mined interactions from Literome

Chen et al., J Cell Physiol 2000 (Adenocarcinoma...) : In the present study, we establish the functional requirement for endogenous Smad3 and Smad4 in TGF-beta stimulated COL1A2 transcription in human skin fibroblasts in vitro
Poncelet et al., J Biol Chem 2001 : Chemical inhibition of Sp1 binding with mithramycin A, or deletion of the GC boxes, inhibited COL1A2 activation by Smad3 , suggesting cooperation between Smad3 and Sp1 in the TGF-beta1 response ... Finally, combined Sp1 and Smad3 overexpression induces marked ligand independent and ligand dependent promoter activity of COL1A2
Runyan et al., American journal of physiology. Renal physiology 2003 : Blockade of PKCdelta abolished ligand independent and ligand dependent stimulation of COL1A2 promoter activity by Smad3
Wendling et al., Mol Pharmacol 2003 : Together, these results identify 5-FU as a potent inhibitor of TGF-beta/SMAD signaling, capable of blocking TGF-beta induced , SMAD-driven up-regulation of COL1A2 gene expression in a JNK dependent manner
Inagaki et al., Hepatology 2003 (Liver Cirrhosis, Experimental) : Transient transfection assays indicated that IFN-alpha decreased the steady-state levels of COL1A2 messenger RNA ( mRNA ) and inhibited basal and TGF-beta/Smad3 stimulated COL1A2 transcription in activated hepatic stellate cells (HSC) ... In conclusion, our results indicate that IFN-alpha antagonizes the TGF-beta/Smad3 stimulated COL1A2 transcription in vitro and suppresses COL1A2 promoter activation in vivo, providing a molecular basis for antifibrotic effects of IFN-alpha
Kanamaru et al., Nephron. Experimental nephrology 2003 : The functional role of p300 in TGF-beta1/Smad-pathway mediated COL1A2 transcription was investigated in cotransfection experiments using a COL1A2 promoter-luciferase reporter gene construct and p300 expression plasmids ... TGF-beta1 induced interaction of endogenous p300 with Smad2/3 , and a dominant negative construct of p300 inhibited the TGF-beta1 induced COL1A2 expression in cultured mouse mesangial cells
Ihn et al., Rheumatology (Oxford) 2006 (Scleroderma, Systemic) : The overexpression of Smad3 caused an increase of up to 5-fold in COL1A2 promoter activity in normal fibroblasts, while Smad3 caused a small increase in COL1A2 promoter activity in SSc fibroblasts
Lee et al., J Ethnopharmacol 2007 : Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Ponticos et al., Arthritis Rheum 2009 (Disease Models, Animal...) : The enhanced Col1a2 promoter activity in fibroblasts from bleomycin treated lungs was partly dependent on Smad signaling, whereas CTGF acted on the Col1a2 promoter by a mechanism that was independent of the Smad binding site, but was, instead, dependent on the ERK-1/2 and JNK MAPK pathways
Chen et al., J Invest Dermatol 1999 : Overexpression of a phosphorylation-deficient Smad 3 mutant or wild-type Smad 7, which lacks the carboxy-terminal phosphorylation motif, specifically inhibited TGF-beta induced activation of COL1A2 promoter