Gene interactions and pathways from curated databases and text-mining

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PPARA — RELA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Cabrero et al., J Biol Chem 2002 : These results indicate that ROS generation and NF-kappaB activation are responsible for the down-regulation of PPARalpha and may provide a new mechanism by which intracellular lipid accumulation occurs in skeletal muscle cells
Kleemann et al., Blood 2003 : First, PPAR-alpha increases IkappaB-alpha expression and thus prevents p50-NFkappaB translocation to the nucleus ... Our findings identify C/EBP-beta and p50-NFkappaB as novel targets for PPAR-alpha and provide a molecular explanation for the reduction of plasma CRP levels by fibrates
Sethi et al., Redox Rep 2002 : We propose that oxidation of EPA and its activation of PPARalpha and subsequent inhibition of NF-kappaB is the underlying mechanism for the beneficial effects of fish oil
Cabrero et al., Curr Drug Targets Inflamm Allergy 2002 (Inflammation) : PPARalpha activation results in the repression of NF-kappaB signaling and inflammatory cytokine production in different cell-types
Vlaeminck-Guillem et al., Med Sci (Paris) 2003 (Cell Transformation, Neoplastic...) : For instance, glucocorticoid and PPAR receptors repress the transcription activity of the pro-inflammatory factor NF-kappa B
Mishra et al., Arterioscler Thromb Vasc Biol 2004 : Furthermore, oxidized EPA inhibited NF-kappaB activation in endothelial cells derived from wild-type mice but had no inhibitory effects on NF-kappaB activation in endothelial cells derived from peroxisome proliferator activated receptor alpha ( PPARalpha ) -deficient mice, indicating that oxidized EPA requires PPARalpha for its inhibitory effects on NF-kappaB
Keshamouni et al., Neoplasia (New York, N.Y.) 2005 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, PPAR-gamma activation inhibited NF-kappa B transcriptional activity, as assessed by TransAM reporter gene assay
Huang et al., J Biomed Sci 2006 : Besides regulating lipid metabolism, peroxisome proliferator activated receptor ( PPAR)-alpha activators also reduce NF-kappaB activation to terminate activation of inflammatory pathways
Wild et al., World J Gastroenterol 2007 (Inflammation...) : Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have stressed the role of PPAR on NFkappaB activity on the potential beneficial effect of dietary lipids on intestinal function
Razeghi et al., Cardiovasc Res 2007 : Lack of NF-kappaB1 ( p105/p50 ) attenuates unloading induced downregulation of PPARalpha and PPARalpha regulated gene expression in rodent heart
Dubrac et al., J Immunol 2007 : Moreover, PPARalpha activation inhibits NF-kappaB but not stress activated protein kinase/JNK, p38MAPK, and ERK1/2
Lin et al., Mol Pharmacol 2007 : PPAR-alpha overexpression also inhibited the doxorubicin induced activity of nuclear factor-kappaB (NF-kappaB) , which was associated with the interaction between PPAR-alpha and NF-kappaB p65 subunit as revealed in immunoprecipitation assays
Rodríguez-Calvo et al., J Gerontol A Biol Sci Med Sci 2007 (Cardiomegaly) : These findings suggest that NF-kappaB activation in SAM-P8 heart prevents PPARalpha from binding to its response elements leading to changes in gene expression that may lead to ceramide accumulation in the aged heart
Okayasu et al., Life Sci 2008 : PPARalpha activators upregulate eNOS activity and inhibit cytokine induced NF-kappaB activation through AMP activated protein kinase activation
Shen et al., J Am Coll Nutr 2008 (Atherosclerosis...) : PPAR can inhibit NF-kappaB signaling, and our previous data have shown that PPAR transactivation activity requires adequate zinc
Remels et al., Am J Physiol Endocrinol Metab 2009 : The goal of the present study, therefore, was to evaluate whether PPAR activation affects cytokine induced NF-kappaB activity in skeletal muscle
Ramdhan et al., Environ Health Perspect 2010 (Body Weight...) : NFkappaB-p52 is a candidate molecular marker for inflammation caused by TRI, and PPARalpha may be involved in TRI induced hepatosteatosis