Ikegawa et al., Clinical calcium 2006
(Genetic Predisposition to Disease...) :
Asporin co-localized to and bound to TGF-beta, and inhibited TGF-beta-Smad signal
Kou et al., J Biol Chem 2007
(Osteoarthritis) :
Inhibition of Smad3 significantly reduced TGF-beta1 induced ASPN expression, whereas overexpression of Smad3 augmented the induction
Nakajima et al., J Biol Chem 2007
(Osteoarthritis, Knee) :
Asporin inhibits TGF-beta/Smad signaling upstream of TGF-beta type I receptor activation in vivo by co-localizing with TGF-beta1 on the cell surface and blocking its interaction with the TGF-beta type II receptor