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BMP2 — DKK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hufton et al., BMC developmental biology 2006
:
To this end, we ectopically overexpress Noggin and
Dkk-1 ,
inhibitors of the
BMP and Wnt pathways, respectively, within ventral tissues
Fujita et al., Molecular cancer 2007
(Plasmacytoma) :
Dkk1 and -2 increased the expression of the osteoclast differentiation factors, receptor activator of NF-kappaB ligand ( RANKL ) and macrophage-colony stimulating factor ( M-CSF ), upon
stimulation with Wnt3a/1,25-dihydroxyvitamine D3 and
Wnt3a/BMP2 , respectively
Dai et al., Cancer Res 2008
(Neoplasm Metastasis...) :
DKK-1 blocked Wnt activation of the
BMP promoters ... The addition of
DKK-1 and Noggin, a
BMP inhibitor , to CM diminished PCa CM-induced osteoblast differentiation in a synergistic fashion
Kamiya et al., J Bone Miner Res 2010
:
These effectors are differentially regulated by mitogen activated protein kinase ( MAPK ) p38 because pretreatment of osteoblasts with SB202190 blocked
BMP2 induced
Dkk1 expression but not Sost
Miura et al., Dev Biol 2010
:
These data indicate that
BMP signaling in the epiblast
induces Wnt3 and Wnt3a expression to maintain WNT signaling in the VE, resulting in downregulation of
Dkk1 to establish the anterior expression domain ... Thus, our results suggest that
BMP signaling
regulates the expression patterns of
Dkk1 for anterior migration of the AVE