Will et al., J Immunol 2006
:
Importantly, this model predicts that preventing pre-BCR dependent down-regulation of IL-7R signaling should interfere with allelic exclusion
Matsuguchi et al., J Biol Chem 1994
(Leukemia, Megakaryoblastic, Acute) :
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL Marshall et al., J Immunol 1998
:
Thus, the pre-BCR dependent modulation of IL-7 responsiveness affects both the dose-response threshold and the duration of IL-7 induced clonal expansion