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ITGB1 — PLAU

Pathways - manually collected, often from reviews:

• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) (modification, collaborate)
  Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → alpha5/beta1 Integrin complex (ITGA5-ITGB1) (modification, collaborate)
  Monaghan et al., J Biol Chem 2004*, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Monaghan et al., J Biol Chem 2004*, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha5/beta1 Integrin complex (ITGA5-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Monaghan et al., J Biol Chem 2004*, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → alpha5/beta1 Integrin complex (ITGA5-ITGB1) (modification, collaborate)
  Monaghan et al., J Biol Chem 2004*, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Monaghan et al., J Biol Chem 2004*, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alpha5/beta1 Integrin complex (ITGA5-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Monaghan et al., J Biol Chem 2004*, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → alpha3/beta1 Integrin complex (ITGA3-ITGB1) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha3/beta1 Integrin complex (ITGA3-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → uPA/uPAR/alpha3/beta1 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGA3-ITGB1) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996, Xue et al., Cancer Res 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → Vitronectin (VTN) (modification, collaborate) Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996, Xue et al., Cancer Res 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha3/beta1 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGA3-ITGB1) → Vitronectin (VTN) (modification, collaborate) Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996, Xue et al., Cancer Res 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alpha3/beta1 Integrin complex (ITGA3-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, activates)
  Mazzieri et al., Mol Biol Cell 2006
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → alpha3/beta1 Integrin complex (ITGA3-ITGB1) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: alpha3/beta1 Integrin complex (ITGA3-ITGB1) → uPA/uPAR complex (PLAUR-PLAU) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) (modification, collaborate)
  Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → uPA/uPAR/alpha3/beta1 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGA3-ITGB1) (modification, collaborate)
  Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996, Xue et al., Cancer Res 1997
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha3/beta 1 Integrin complex (PLAUR-PLAU-ITGA3-ITGB1) → Vitronectin (VTN) (modification, collaborate) Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996, Xue et al., Cancer Res 1997
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha3/beta1 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGA3-ITGB1) → Vitronectin (VTN) (modification, collaborate) Wei et al., Mol Biol Cell 2001, Mazzieri et al., Mol Biol Cell 2006, Wei et al., Science 1996, Xue et al., Cancer Res 1997
  Evidence: physical interaction

Text-mined interactions from Literome

Ghosh et al., J Biol Chem 2000 (Precancerous Conditions) : Urinary-type plasminogen activator (uPA) expression and uPA receptor localization are regulated by alpha 3beta 1 integrin in oral keratinocytes
Ghosh et al., J Biol Chem 2006 : Because multivalent aggregation of alpha3beta1 integrin up-regulates uPA and induces a dramatic co-clustering of uPAR, we explored the hypothesis that lateral ligation of alpha3beta1 integrin by uPAR contributes to uPA regulation in oral mucosal cells