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ITGB1 — VCAM1

Pathways - manually collected, often from reviews:

• KEGG Cell adhesion molecules (CAMs): Complex of ITGA4-ITGB1 → VCAM1 (protein-protein, activation)
• KEGG Cell adhesion molecules (CAMs): Complex of ITGA9-ITGB1 → VCAM1 (protein-protein, activation)
• KEGG Leukocyte transendothelial migration: VCAM1 → Complex of ITGA4-ITGB1 (protein-protein, binding/association)
• NCI Pathway Database Alpha4 beta1 integrin signaling events: LRP (PTPRA) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, activates)
  Pereira et al., J Immunol 2001, Hsia et al., Mol Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Beta1 integrin cell surface interactions: VCAM1 (VCAM1) → alpha4/beta1 Integrin complex (ITGA4-ITGB1) (modification, collaborate)
  Sriramarao et al., Blood 2000*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: VCAM1 (VCAM1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Sriramarao et al., Blood 2000*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha4/beta1 Integrin complex (ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Sriramarao et al., Blood 2000*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
  Evidence: physical interaction
• NCI Pathway Database a4b7 Integrin signaling: alpha4/beta1 Integrin/Paxillin/VCAM1 complex (ITGB1-VCAM1) → VCAM1 (VCAM1) (modification, collaborate) Abonia et al., Blood 2006*, Pinola et al., Scand J Immunol 1994*, Postigo et al., J Immunol 1993
• NCI Pathway Database a4b7 Integrin signaling: alpha4/beta1 Integrin/Paxillin/VCAM1 complex (ITGB1-VCAM1) → alpha4/beta7 Integrin/Paxillin complex (ITGB7) (modification, collaborate)
  Abonia et al., Blood 2006*, Pinola et al., Scand J Immunol 1994*, Postigo et al., J Immunol 1993
• NCI Pathway Database Alpha4 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha4/beta1 Integrin complex (ITGA4-ITGB1) (modification, collaborate)
  Hsia et al., Mol Cell Biol 2005, Ring et al., Proc Natl Acad Sci U S A 2011
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Hsia et al., Mol Cell Biol 2005, Ring et al., Proc Natl Acad Sci U S A 2011
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin complex (ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Hsia et al., Mol Cell Biol 2005, Ring et al., Proc Natl Acad Sci U S A 2011
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Talin (TLN1) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Talin (TLN1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → FAK (PTK2) (modification, activates) Rose et al., J Immunol 2003, Nojima et al., Cell Immunol 1995*, Manie et al., Blood 1996
  Evidence: mutant phenotype
• NCI Pathway Database Beta1 integrin cell surface interactions: VCAM1 (VCAM1) → alpha9/beta1 Integrin complex (ITGA9-ITGB1) (modification, collaborate)
  Taooka et al., J Cell Biol 1999*, Palmer et al., J Cell Biol 1993
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: VCAM1 (VCAM1) → alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1) (modification, collaborate)
  Taooka et al., J Cell Biol 1999*, Palmer et al., J Cell Biol 1993
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alpha9/beta1 Integrin complex (ITGA9-ITGB1) → alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1) (modification, collaborate)
  Taooka et al., J Cell Biol 1999*, Palmer et al., J Cell Biol 1993
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: ABI1 (ABI1) → alpha4/beta1 Integrin/VCAM1/ABI1 complex (VCAM1-ABI1-ITGA4-ITGB1) (modification, collaborate)
  Ring et al., Proc Natl Acad Sci U S A 2011
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: ABI1 (ABI1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Ring et al., Proc Natl Acad Sci U S A 2011
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/ABI1 complex (VCAM1-ABI1-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Ring et al., Proc Natl Acad Sci U S A 2011
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → PYK2 (PTK2B) (modification, activates) Kanda et al., Biochem Biophys Res Commun 2003*, Rose et al., J Immunol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Paxillin (PXN) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha9/beta1 Integrin complex (ITGA9-ITGB1) (modification, collaborate)
  Taooka et al., J Cell Biol 1999*
  Evidence: physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1) (modification, collaborate)
  Taooka et al., J Cell Biol 1999*
  Evidence: physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: alpha9/beta1 Integrin complex (ITGA9-ITGB1) → alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1) (modification, collaborate)
  Taooka et al., J Cell Biol 1999*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Thrombospondin complex (ITGA4-ITGB1-THBS1) → VCAM1 (VCAM1) (modification, collaborate) Li et al., J Cell Biol 2002
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha4/beta1 Integrin complex (ITGA4-ITGB1) (modification, collaborate)
  Li et al., J Cell Biol 2002
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha4/beta1 Integrin complex (ITGA4-ITGB1) (modification, collaborate)
  Sriramarao et al., Blood 2000*, Sengbusch et al., J Cell Biol 2002*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Chigaev et al., J Immunol 2007*, Lomakina et al., Biophys J 2009*, García-Bernal et al., Immunity 2009*, Jakubowski et al., Cell adhesion and communication 1995*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: VCAM1 (VCAM1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Sriramarao et al., Blood 2000*, Sengbusch et al., J Cell Biol 2002*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Chigaev et al., J Immunol 2007*, Lomakina et al., Biophys J 2009*, García-Bernal et al., Immunity 2009*, Jakubowski et al., Cell adhesion and communication 1995*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin complex (ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Sriramarao et al., Blood 2000*, Sengbusch et al., J Cell Biol 2002*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Chigaev et al., J Immunol 2007*, Lomakina et al., Biophys J 2009*, García-Bernal et al., Immunity 2009*, Jakubowski et al., Cell adhesion and communication 1995*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
  Evidence: physical interaction
• Reactome Reaction: ITGB1 → VCAM1 (indirect_complex) Taooka et al., J Cell Biol 1999*, Yusuf-Makagiansar et al., Med Res Rev 2002*, Jones et al., Nature 1995*
• Reactome Reaction: ITGB1 → VCAM1 (reaction) Taooka et al., J Cell Biol 1999*, Yusuf-Makagiansar et al., Med Res Rev 2002*, Jones et al., Nature 1995*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM ITGA4-ITGB1-VCAM1 complex: ITGA4-ITGB1-VCAM1 complex complex (ITGA4-ITGB1-VCAM1) Chan et al., J Immunol 2000*
• MIPS CORUM ITGA9-ITGB1-VCAM1 complex: ITGA9-ITGB1-VCAM1 complex complex (ITGA9-ITGB1-VCAM1) Taooka et al., J Cell Biol 1999*
• IRef Corum Interaction: Complex of ITGA9-VCAM1-ITGB1 (association, affinity chromatography technology) Taooka et al., J Cell Biol 1999*
• IRef Corum Interaction: Complex of ITGB1-ITGA4-VCAM1 (association, affinity chromatography technology) Chan et al., J Immunol 2000*
• IRef Hprd Interaction: Complex of ITGB1-VCAM1-ITGA9-VCAM1-ITGB1-ITGA9-ITGA9-ITGB1-VCAM1 (in vivo) Taooka et al., J Cell Biol 1999*
• IRef Hprd Interaction: ITGB1 — VCAM1 (in vitro) Crook et al., J Vasc Res 2002*, Abe et al., J Bone Miner Metab 2009*
• IRef Hprd Interaction: ITGB1 — VCAM1 (in vivo) Crook et al., J Vasc Res 2002*, Abe et al., J Bone Miner Metab 2009*
• IRef Hprd Interaction: Complex of ITGB1-VCAM1-ITGA4-VCAM1-ITGB1-ITGA4-ITGA4-ITGB1-VCAM1 (in vivo) Chan et al., J Immunol 2000*, Domínguez-Jiménez et al., Cell adhesion and communication 1996*
• IRef Intact Interaction: ITGB1 — VCAM1 (physical association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 185 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of ITGB1-PXN-ITGA4-VCAM1 (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of TLN1-ITGB1-VCAM1-ZYX (association, pull down) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 177 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 168 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Ophid Interaction: ITGB1 — VCAM1 (aggregation, confirmational text mining) Chan et al., J Immunol 2000*
• IRef Ophid Interaction: ITGB1 — VCAM1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Chuang et al., Blood 2004 : By using monoclonal antibodies and recombinant intercellular adhesion molecule 1 ( ICAM-1 ) to engage lymphocyte function associated antigen 1 ( LFA-1 ) on monocytic cells, we found that the cellular adhesion to vascular cell adhesion molecule 1 ( VCAM-1 ) mediated by very late antigen 4 (VLA-4) was suppressed after this treatment and the suppression depended on the presence of reactive oxygen species ( ROSs )
Miura et al., Pediatr Infect Dis J 2004 (Coronary Aneurysm...) : Our results suggest that E-selectin and VCAM-1 expression on neovasculature may contribute to neoangiogenesis and prolonged CAA inflammation and that integrin beta1 might be involved in fibroblastic remodeling of acute KD CAA
Sasaki et al., J Immunother 2009 (Melanoma, Experimental) : Predictably, among the Th populations evaluated, Th1 cells alone adhered efficiently to, and were costimulated by, plate bound VCAM-1 and laminin in a VLA-4 dependent or VLA-6 dependent manner, respectively
Nakajima et al., J Exp Med 1994 : These results indicate that VCAM-1/VLA-4 interaction plays a predominant role in controlling antigen induced eosinophil and T cell recruitment into the tissue and that the induction of VCAM-1 expression on the endothelium at the site of allergic inflammation regulates this eosinophil and T cell recruitment
van Seventer et al., Eur J Immunol 1998 : Stimulation of Jurkat T cells with the alpha4beta1 integrin ligand VCAM-1 results in Pyk2 tyrosine phosphorylation, and combined stimulation with VCAM-1 and anti-CD3 mAb induces rapid and sustained synergistic Pyk2 phosphorylation