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DOK3 — IRF6

Text-mined interactions from Literome

Peng et al., PloS one 2012 : DOK3 negatively regulates LPS responses and endotoxin tolerance ... LPS induces ubiquitin mediated degradation of DOK3 leading to SOS1 degradation and inhibition of ERK activation
Peng et al., Science signaling 2013 : We show that inhibition of LPS responses by DAP12 is mediated by the adaptor protein DOK3 ( downstream of kinase 3 ) ... In response to LPS , DOK3 was phosphorylated in a DAP12- and Src dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane ... In response to LPS , DOK3 was phosphorylated in a DAP12- and Src dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane