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Text-mined interactions from Literome

Hawiger et al., Blood 1999 (Inflammation) : LPS activated IKK complexes phosphorylate all 3 inhibitors of NF-kappaB : IkappaBalpha, IkappaBbeta, and IkappaBepsilon
Jeon et al., J Immunol 2000 : A lipophilic gold compound, auranofin, suppressed the LPS induced increase of nuclear kappa B-binding activity, degradation of I kappa B proteins, and IKK activation
Torrie et al., Br J Pharmacol 2001 : Preincubation of RASMC with H ( 2 ) O ( 2 ) inhibited LPS stimulated IKK kinase activity and downstream NF-kappaB-DNA binding activity ... Effective inhibition of this pathway using SB203580 did not reverse the effects of H ( 2 ) O ( 2 ) on LPS stimulated IKK/NF-kappaB signalling
Chen et al., Br J Pharmacol 2001 : In this study, we investigated the upstream kinases for IKK activation by UTP and LPS ... BAPTA/AM and KN-93 ( a calcium/calmodulin dependent protein kinase ( CaMK ) inhibitor ) attenuated UTP- but not LPS stimulated IKK activity ... 6. Taken together, we demonstration that Gq protein coupled P2Y(6) receptor activation can potentiate LPS stimulated IKK activity ... While PKC and ERK participate in IKK activation by LPS and UTP, the phosphatidylinositide-phospholipase C-dependent activation of CaMK plays a major role in UTP potentiation of the LPS response
Yang et al., J Immunol 2003 : Activation of the I kappa B kinase (IKK) complex by LPS induces phosphorylation and degradation of I kappa B alpha, leading to the nuclear translocation of NF-kappa B
MacKenzie et al., Br J Pharmacol 2003 (MAP Kinase Signaling System) : 3. Another inhibitor of NFkappaB signalling, the serine protease inhibitor Nalphap-tosyl-L-lysine chloro-methylketone ( TLCK ), also inhibited LPS stimulated IKK activity and potentiated JNK activity in response to LPS, suggesting that cross-talk may occur between the NFkappaB and stress activated protein kinase pathways at the level of IKK or at a common point upstream
Chen et al., Br J Pharmacol 2003 : 6. The kinase assay indicated that ERK, JNK, and IKK activation by LPS were inhibited by vanilloids
Yang et al., J Immunol 2004 : The activation of the I-kappaB kinase (IKK) complex by TNF or LPS stimulates phosphorylation and degradation of I-kappaBalpha, leading to the nuclear translocation of NF-kappaB
Hattori et al., Cardiovasc Res 2004 : LPS stimulates IkappaB-alpha phosphorylation by inducing IkappaB kinase (IKK) activity, and NO, but not ONOO-, inhibits LPS induced IkappaB-alpha phosphorylation and IKK activity
Kim et al., Immunology 2005 : Using bone-marrow derived dendritic cells ( BMDCs ) isolated from interleukin (IL)-10 ( -/- ) mice or from recently engineered transgenic mice expressing the enhanced green fluorescent protein ( EGFP ) under the transcriptional control of NF-kappaB cis-elements ( cis-NF-kappaB ( EGFP ) ), we found that luteolin blocks LPS induced IkappaB phosphorylation and IKK activity, and decreases EGFP, IL-12 and tumour necrosis factor-alpha gene expression
Chen et al., Eur J Pharmacol 2005 : LPS induced IkappaB kinase (IKK) , nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1) activation , and IFN-gamma induced NF-kappaB, signal transducer and activator of transcription-1 ( STAT1 ) and interferon regulatory factor-1 (IRF-1) activation were reduced by quercetin
Chang et al., J Dent Res 2005 : We found that both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylation and degradation of IkappaBalpha, resulting in the nuclear translocation of NF-kappaB
Kim et al., Biochem Biophys Res Commun 2007 : ATM inhibited the kinase activity of highly purified IKKbeta and also LPS induced IKK activity in the cells
Peng et al., J Gastrointest Surg 2007 (Sepsis...) : AdPKC-zeta DN attenuated the LPS induced upregulation of PKC-zeta activity, IKKbeta, IKKgamma , NF-kappaB, Fas/FasL, Caspase-3, and DNA fragmentation in Kupffer cells ( all p < 0.001 ), whereas overexpression of PKC-zeta augmented LPS induced upregulation of IKKbeta, IKKgamma, NF-kappaB, Caspase-3, and DNA fragmentation ( p < 0.001 )
Cordier et al., J Mol Biol 2008 (Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive...) : This is sufficient to alter NEMO function, since functional complementation assays using NEMO-deficient pre-B and T lymphocytes show that full-length C417F pathogenic NEMO leads to a partial to strong defect in LPS , IL-1beta and TNF-alpha induced NF-kappaB activation, respectively, as compared to wild type NEMO
Oh et al., Neurosci Lett 2009 : We showed that OA blocked LPS induced NF-kappaB activation and phosphorylation of inhibitor kappaB kinase (IKK)
Oh et al., Neurosci Lett 2010 (Inflammation) : We showed that oleamide blocked LPS induced NF-kappaB activation and phosphorylation of inhibitor kappaB kinase (IKK)
Shin et al., Int Immunopharmacol 2010 : Furthermore, pretreatment with sulfuretin significantly inhibited the LPS stimulated activation of I kappaB kinase beta (IKK beta)
López-Peláez et al., Eur J Immunol 2011 : LPS stimulation activates IKK and different MAP kinase pathways, as well as the PI3K-Akt-mTOR-p70 S6k pathway, a negative regulator of these MyD88 dependent intracellular signals
Shin et al., J Cell Biochem 2011 : Furthermore, pelubipofen inhibited the LPS induced phosphorylation of IKK-ß and transforming growth factor-ß activated kinase-1 ( TAK1 )
Khan et al., J Ethnopharmacol 2013 (Edema...) : Capillarisin suppressed LPS induced inhibitory kappa kinase (IKK) phosphorylation and the degradation of inhibitory kappa B ( I?Ba ) and prevented the nuclear translocation of p65 and p50
Lee et al., J Ethnopharmacol 2013 (Disease Models, Animal...) : Treatment of primary macrophages with TCC in vitro significantly inhibited all of the inflammatory parameters measured, including LPS induced NO and PGE ( 2 ) production, iNOS and COX-2 expression, I?Ba degradation, IKK phosphorylation, and MAPK and STAT1 activation
Menden et al., Am J Physiol Lung Cell Mol Physiol 2013 : We examined whether Nox2 dependent, LPS mediated IKK-ß phosphorylation was regulated by protein phosphatase 2A (PP2A) or TGF-ß associated kinase-1 (TAK1) in HPMEC
O'Connell et al., J Biol Chem 1998 : Here, we report that LPS induces IKK activity in human monocytes and THP-1 monocytic cells