◀ Back to TP53

TFRC — TP53

Text-mined interactions from Literome

Perry et al., J Biol Chem 2000 : p90 ( MDM2 ) inhibits p53 by blocking the transcriptional activation domain of p53 as well as by stimulating its degradation
Mendrysa et al., Mol Cell Biol 2003 (Body Weight) : Here we provide the first conclusive demonstration that p90MDM2 constitutively regulates p53 activity in homeostatic tissues ... Cre mediated deletion of mdm2 caused a greater accumulation of p53, demonstrating that p90MDM2 constitutively regulates both the activity and the level of p53 in homeostatic tissues
Friedman et al., Translational oncology 2013 : Prodrug SNX5422 similarly down modulated key signal targets, enhanced TP53 expression and apoptosis, and inhibited proliferation, angiogenesis, and tumorigenesis in a wtTP53-deficient HNSCC xenograft model