Maurer et al., J Biol Chem 2001
:
Thus, induction of VDR by WT1 leads to an enhanced response to 1,25-dihydroxyvitamin D ( 3 )
Wagner et al., J Am Soc Nephrol 2001
(Wilms Tumor) :
Activation of vitamin D receptor by the Wilms ' tumor gene product mediates apoptosis of renal cells ... These findings suggest that transcriptional activation of the VDR by WT1 can mediate programmed death of renal embryonic cells in response to 1,25- ( OH ) ( 2 ) D ( 3 )
Lee et al., Physiol Genomics 2001
(Denys-Drash Syndrome...) :
Nuclear run on experiments demonstrated that the effect of WT1 on VDR expression is at the transcriptional level ... We also show that the products of a Denys-Drash syndrome allele of wt1 inhibit WT1 mediated transactivation of the human VDR promoter