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ADAMTS7 — TNF

Text-mined interactions from Literome

Bevitt et al., Biochim Biophys Acta 2003 : The expression of ADAMTS genes in ARPE-19 cells and the transcriptional stimulation of some family members by TNFalpha may implicate them in inflammatory eye disease and the compromise of retinal matrix structure, which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies
Luan et al., Osteoarthritis Cartilage 2008 : The suppression of ADAMTS-7 or ADAMTS-12 expression by siRNA silencing in the human chondrocytes also prevented TNF-alpha- or IL-1beta induced COMP degradation
Guo et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid...) : To determine 1 ) whether a protein interaction network exists between granulin-epithelin precursor (GEP), ADAMTS-7/ADAMTS-12, and cartilage oligomeric matrix protein ( COMP ) ; 2 ) whether GEP interferes with the interactions between ADAMTS-7/ADAMTS-12 metalloproteinases and COMP substrate, including the cleavage of COMP ; 3 ) whether GEP affects tumor necrosis factor alpha (TNFalpha) mediated induction of ADAMTS-7/ADAMTS-12 expression and COMP degradation ; and 4 ) whether GEP levels are altered during the progression of arthritis ... The role of GEP in inhibiting TNFalpha induced ADAMTS-7/ADAMTS-12 expression and COMP degradation in cartilage explants was also analyzed ... More importantly, GEP inhibited COMP degradation by ADAMTS-7/ADAMTS-12 in a dose dependent manner through 1 ) competitive inhibition through direct protein-protein interactions with ADAMTS-7/ADAMTS-12 and COMP, and 2 ) inhibition of TNFalpha induced ADAMTS-7/ADAMTS-12 expression