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PPARA — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hill et al., Infect Immun 1999
(Endotoxemia) :
Therefore, we examined the
role of
PPARalpha activators on the regulation of
TNF expression in a mouse model of endotoxemia ... Utilizing PPARalpha wild-type ( WT ) and knockout ( KO ) mice, we showed that the effect of fenofibrate on LPS induced
TNF expression was indeed
mediated by
PPARalpha
Nawa et al., Biochem Biophys Res Commun 2000
:
Repression of
TNF-alpha induced E-selectin expression by
PPAR activators : involvement of transcriptional repressor LRF-1/ATF3
Rusyn et al., Antioxid Redox Signal 2000
(Liver Neoplasms) :
However,
PPARalpha is not
involved in
TNF-alpha production by Kupffer cells because it is not expressed in this cell type
Nakatani et al., J Biol Chem 2002
:
In in vivo studies,
PPARalpha activators moderately
up-regulated TNFalpha mRNA expression in mouse liver
Giri et al., J Immunol 2004
:
Ligands for peroxisome proliferator activated receptor gamma ( PPARgamma ), such as 15-deoxy-12,14-PGJ2 ( 15d-PGJ2 ), have been proposed as a new class of anti-inflammatory compounds because 15d-PGJ2 was able to inhibit the induction of inflammatory response genes such as inducible NO synthase (iNOS) and
TNF ( TNF-alpha ) in a
PPAR dependent manner in various cell types
Lee et al., Neuroreport 2005
(Inflammation) :
PPAR-alpha activators also
suppressed lipopolysaccharide stimulated
tumor necrosis factor-alpha and monocyte chemoattractant protein-1 transcription and release
Lu et al., J Lipid Res 2006
(Acute-Phase Reaction) :
Moreover,
TNF-alpha significantly
reduces PPAR and LXR response element-driven transcription
Schrader et al., Biochim Biophys Acta 2006
:
The latter response is related to the suppressive
effects of
TNFalpha on peroxisomal function and on
PPARalpha
Murakami et al., Eur J Pharmacol 2007
(Insulin Resistance) :
We studied the
effect of the
PPARalpha activation of macrophages on the modulation of the
tumor necrosis factor alpha (TNFalpha) expression in adipocytes using a cell culture system ... The
PPARalpha activators may
suppress the pathogenetical secretion of
TNFalpha in the adipocytes through the functional modulation of the infiltrated macrophages
Wang et al., Zhonghua Wai Ke Za Zhi 2007
(Carcinoma, Hepatocellular...) :
TNF-alpha could
induce down-regulation of MDR1 and up-regulation of
PPAR-alpha
Huang et al., J Neurochem 2008
:
Importantly, increased
PPAR activity
attenuated induction of IL-1beta,
tumor necrosis factor-alpha , CCL2, and E-selectin in hCMEC/D3 cells co-cultured with HIV-1 infected Jurkat cells
Lee et al., Eur J Clin Invest 2009
:
However, co-administration of ascorbic acid prevented the
effect of
TNF-alpha both on
PPAR-alpha and PPAR-gamma
Chen et al., American journal of physiology. Renal physiology 2009
(Reperfusion Injury) :
PPAR-alpha reduced the NF-kappaB induced overexpression of
TNF-alpha and apoptosis in cultured kidney cells
Mogilenko et al., Biochemistry 2009
:
A chromatin immunoprecipitation assay demonstrates that
TNFalpha leads to a 2-fold decrease in the level of
PPARalpha binding with the apoA-I gene hepatic enhancer
Qin et al., Experimental biology and medicine (Maywood, N.J.) 2010
:
TNF-alpha also
induced Cd36 and peroxisome proliferators activated receptor (
Ppar)gamma expression, as well as microsomal triglyceride transfer protein ( Mtp ) protein and mRNA, but suppressed the sterol regulatory element binding protein ( Srebp)1c protein and mRNA level
Xiao et al., Mol Biol Rep 2011
:
The results showed troglitazone activated
PPAR? could
inhibit the production of
TNF-a , one of the most important inflammatory factors, and then increased the expression of surfactant associated protein A ( SP-A ) and attenuate the apoptosis of alveolar type II epithelial cells
Bassaganya-Riera et al., Br J Nutr 2011
(Inflammation...) :
PUA ameliorated spontaneous pan-enteritis in IL-10 ( -/- ) mice and DSS colitis, up-regulated Foxp3 expression in Treg and
suppressed TNF-a , but the loss of functional
PPAR? or d impaired these anti-inflammatory effects
Borland et al., Cell Signal 2011
:
However, these studies demonstrate that stable over-expression of PPARß/d or
PPAR? significantly increases the efficacy of ligand activation and
represses UVB induced expression of
tumor necrosis factor a (TNFa) , interleukin 6 (IL6), or IL8 in HaCaT keratinocytes, thereby establishing an excellent model to study the functional role of these receptors in human keratinocytes
Matsunaga et al., Mol Med Report 2012
:
?-tocotrienol effectively improved the
TNF-a induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6, adiponectin and
PPAR? mRNA expression
Lai et al., Horm Metab Res 2013
(Fatty Liver) :
Direct
effect of
TNF-a on
PPAR-d expression was also characterized in RMC cell
Mao et al., Gastroenterology research and practice 2012
:
Furthermore, in the rosiglitazone treatment group, DAI and CMDI decreased significantly on the 14-day, 21-day, and 35-day timepoints compared to the UC model group ; the colonic expression of NF-?B and
TNF-a decreased compared to UC model group at all timepoints, but the
PPAR? expression
increased significantly
Su et al., Basic Res Cardiol 2013
(Cardiomyopathies...) :
In H9c2 cells,
tumor necrosis factor-alpha ( TNF-a ) strongly inhibited CTRP9 expression ( > 60 % ), and significantly
reduced peroxisome proliferator activated receptor-gamma (
PPAR? ), a known transcription factor promoting adiponectin expression ... The inhibitory
effect of
TNF-a on
PPAR? and CTRP9 was reversed by Tiron or rosiglitazone
Beier et al., FEBS Lett 1997
:
In contrast, the mRNA for beta-actin was markedly increased implying that the
effect of
TNF on
PPAR-alpha and the peroxisomal mRNAs is highly selective