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IRF6 — TNFSF10
Text-mined interactions from Literome
Halaas et al., Scand J Immunol 2000
:
Flow cytometric analysis showed low surface and high intracellular levels of
APO2L , and
LPS increased the expression of both ...
LPS also
stimulated the release of soluble
APO2L from the monocytes and macrophages
Ehrlich et al., Cytokine 2003
:
In particular, not only PHA+IL-2 but also
LPS were able to induce secretion of soluble TRAIL, but did not
enhance the expression of surface bound
TRAIL
Halaas et al., Scand J Immunol 2004
:
LPS also
prevented release of
TRAIL from GBS stimulated monocytes
Zheng et al., Zhonghua Gan Zang Bing Za Zhi 2005
(Carcinoma, Hepatocellular...) :
LPS only slightly
increased membrane bound
TRAIL expression of macrophages ... On the other hand, soluble
TRAIL in the supernatant was
increased with
LPS stimulation, and the optimal concentration of LPS was 100 ng/ml ( sTRAIL value 67.40 ng/ml+/-5.08 ng/ml ) ...
LPS increases the expression of soluble
TRAIL in macrophages, and soluble TRAIL is toxic to HepG2 cells
Tsuno et al., J Immunother 2009
(Adenocarcinoma...) :
In IFN-alpha treated OVCAR3 cells,
IRF9-RNAi inhibited transcription of
TRAIL whereas Stat1-RNAi did not, suggesting that the transcription of TRAIL induced by IFN-alpha predominantly required IRF9
Cho et al., Immunology 2010
:
TRAIL expression was strongly induced in DCs upon
stimulation with
lipopolysaccharide (LPS) or Polyinosine-polycytidylic acid ( poly ( I:C ) ) stimulation