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CCL5 — IRF6

Text-mined interactions from Literome

Fessele et al., FASEB J 2001 : In human monocytes, RANTES/CCL5 transcription is up-regulated rapidly and transiently in response to LPS ... Induced Rel p50/p50 binding to site R ( B ) is required for LPS regulation of RANTES/CCL5 transcription
Patole et al., J Am Soc Nephrol 2005 (Autoimmune Diseases...) : In macrophages, G-rich DNA suppressed CpG-DNA-but not LPS induced production of CCL5 in a dose dependent manner
Nencioni et al., Blood 2006 : LPS induced CCL-2/MCP-1 and CCL5/RANTES secretions by DCs were prevented by DC treatment with bortezomib
Park et al., J Pineal Res 2007 : Melatonin pretreatment ( 2696.2 +/- 385.3 pg/mL ) also inhibited the LPS induced secretion of CCL5 ( 4679.6 +/- 107.5 pg/mL ) ... Taken together, these results suggest that melatonin may have a suppressive effect on LPS induced expression of CC chemokine genes, especially CCL2 and CCL5 , which may explain its beneficial effects in the treatment of various inflammatory conditions
Stockmann-Juvala et al., Food Chem Toxicol 2008 : Moreover, FB ( 1 ) inhibited the LPS induced expression of IL-6, IL-1beta, CCL3 and CCL5
Xu et al., J Immunol 2008 (Endotoxemia) : Poly ( I:C ) -induced IFN-beta and LPS induced CCL5 production were also suppressed by PGE ( 2 )
Wang et al., Br J Pharmacol 2009 (Acute Kidney Injury) : Inhibiting GSK-3 reduced LPS induced tumour necrosis factor-alpha (TNF-alpha) and CCL5/RANTES ( released upon activation of normal T-cells ) in vivo in mice and in vitro in murine kidney cortical collecting duct epithelial M1 cells
Qian et al., J Biol Chem 2011 (Bacterial Infections...) : Our data further demonstrated that the soluble factors secreted by mammary gland tumor cells but not normal mammary gland epithelial cells inhibited CCL5 expression in macrophages in response to LPS , but not to TNF-a stimulation ... The inhibitory effect of tumor secreted molecules on LPS induced CCL5 expression was regulated at the post-transcriptional level ... Blocking PGE ( 2 ) synthesis by NS398 or through the use of PGE ( 2 ) receptor antagonists AH-6809 ( EP2 antagonist ) and AH-23848 ( EP4 antagonist ) completely reversed the inhibitory effect of tumor conditioned medium ( TCM ) on LPS induced CCL5 expression ... Moreover, PGE ( 2 ) and the cAMP analog forskolin could mimic tumor mediated CCL5 inhibition, and the inhibitory effects of TCM, PGE ( 2 ), and cAMP analog on LPS induced CCL5 expression could be completely reversed by the PKA inhibitor H89
Min et al., J Pineal Res 2012 : In our studies, we show that melatonin blocked lipopolysaccharide (LPS) induced CCL2 ( monocyte chemotactic protein-1 ; MCP-1 ), CCL5 ( Regulated upon Activation, Normal T-cell Expressed, and Secreted ), and CCL9 ( macrophage inflammatory protein-1? ) chemokine mRNA expression in BV2 murine microglial cells