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FRZB — WNT4

Text-mined interactions from Literome

Yao et al., Development 2001 : The anterior truncation caused by VP16-Gsc was fully rescued by Frzb , a secreted Wnt inhibitor , indicating that activation of ectopic Wnt signaling was responsible, at least in part, for the anterior defects
La et al., Di Yi Jun Yi Da Xue Xue Bao 2004 (Liver Neoplasms) : [ Anti-oncogene p53 induced expression of secreted frizzled related protein , a Wnt signaling inhibitor ]
Rodriguez et al., Nat Neurosci 2005 : Here we show that secreted Frizzled related protein 1 ( SFRP1 ), a proposed Wnt signaling inhibitor , can directly modify and reorient the growth of chick and Xenopus laevis retinal ganglion cell axons
Zi et al., Cancer Res 2005 (Neoplasm Invasiveness...) : The ability of Frzb/secreted Frizzled related protein 3 ( sFRP3 ) to inhibit Wnt signaling and the localization of Frzb/sFRP3 on chromosome 2q to a region frequently deleted in cancers have led some investigators to hypothesize that Frzb/sFRP3 is a tumor suppressor gene
Gumz et al., Clin Cancer Res 2007 (Carcinoma, Renal Cell...) : In an effort to gain a better understanding of signaling events in clear cell RCC ( cRCC ), we investigated the antitumor activity of secreted frizzled related protein 1 ( sFRP1 ), a negative regulator of Wnt signaling
Schlange et al., Breast Cancer Res 2007 (Breast Neoplasms) : Most breast tumors show hypermethylation of the promoter region of secreted Frizzled related protein 1 ( sFRP1 ), a negative WNT pathway regulator , leading to downregulation of its expression
Dufourcq et al., Am J Pathol 2008 (Neovascularization, Pathologic) : Our previous work has shown a role for secreted Frizzled related protein-1 ( sFRP-1 ), a proposed Wnt signaling inhibitor , in neovascularization after an ischemic event and demonstrated its role as a potent angiogenic factor
Trenkmann et al., Ann Rheum Dis 2011 (Arthritis, Rheumatoid) : As a target gene of EZH2 the authors identified secreted frizzled related protein 1 ( SFRP1 ), an inhibitor of Wnt signalling, which is associated with the activation of RASF, and show that SFRP1 expression correlates with the occupation of its promoter with activating and silencing histone marks
Mao et al., Invest Ophthalmol Vis Sci 2012 (Wnt Signaling Pathway) : We previously discovered elevated levels of secreted frizzled related protein 1 ( sFRP1 ), the Wnt signaling pathway inhibitor , in the glaucomatous trabecular meshwork ( GTM ), and found that key canonical Wnt signaling pathway genes are expressed in the trabecular meshwork ( TM )
Shen et al., PloS one 2012 : Such a loss was averted by treatment of secreted Frizzled related protein 1 ( sFRP1 ), an inhibitor of Wnt signaling
Jang et al., Cell stem cell 2013 : Here, we report that neuronal activity decreases the expression of secreted frizzled related protein 3 ( sFRP3 ), a naturally secreted Wnt inhibitor highly expressed by adult dentate gyrus granule neurons
Lin et al., Proc Natl Acad Sci U S A 1997 : In contrast, removal of the C-terminal portion of the molecule preserves both Frzb-Wnt binding and functional inhibition of Wnt signaling