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IL2 — WAS

Text-mined interactions from Literome

McCoy et al., J Pharmacol Exp Ther 1999 : However, THC did not affect interleukin-2 production when the macrophages presented a synthetic peptide of the antigen to the T cells, suggesting that the drug may interfere with antigen processing, not peptide presentation
Nakano et al., Proc Soc Exp Biol Med 1992 : The effects of delta 9-tetrahydrocannabinol (THC) on lymphocyte proliferation and interleukin (IL) 2 activity was investigated using adult murine spleen cells stimulated with either the mitogens concanavalin A, phytohemagglutinin, or anti-CD3 antibody ... These results suggest that the dysregulation in immune responses following THC treatment, either suppression or enhancement, may relate to the effects of THC on IL-2 production
Cannon et al., J Immunol 2004 : Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production ... Defects in IL-2 production are observed even under conditions in which immune synapse formation proceeds normally, suggesting that the role of WASP in regulating IL-2 production is independent of its role in immune synapse formation
Sato et al., FEBS J 2005 : WASP resides in the cytosol as a multifunctional adaptor molecule and mediates actin polymerization and interleukin (IL)-2 synthesis in the T-cell receptor ( TCR ) signaling pathway
Konno et al., Int Immunol 2007 : The notion that WIP promotes WASP function, however, conflicts with evidence that WIP inhibits WASP mediated actin polymerization and IL-2 production and suggests a complex regulation of WASP function by WIP
Dong et al., J Biol Chem 2007 (Wiskott-Aldrich Syndrome) : WASP and its binding partner WIP play important roles in T cells both in actin polymerization and in interleukin-2 transcription
Chen et al., J Leukoc Biol 2012 : THC or CBD suppressed or enhanced IFN-? and IL-2 production by mouse splenocytes under optimal or suboptimal stimulation, respectively
Li et al., Eur J Pharmacol 2013 : Our data demonstrated that THC significantly inhibited LPS induced TNF-a, interleukin-6(IL-6) and nitric oxide ( NO ) production
Régnier-Vigouroux et al., J Immunol 1988 : Assessment of the Ag-specific THC responses in the presence of either live or formaldehyde prefixed APC indicated the following : 1 ) all THC stringently required Ag processing ; 2 ) in 8 of 16 cases, the simple unfolding of apamin was sufficient to eliminate the need for Ag processing, or even induced increased THC IL-2 responses ( other cells required further antigenic alterations in addition to unfolding, or rare processing steps dependent on the integrity of the two disulfide bonds ) ; and 3 ) for most THC, the Leu10 and the N terminus arm of apamin were shown to be critical for expression of the epitopes involved in T cell recognition
Condie et al., J Biol Chem 1996 : Likewise, an inhibition of phorbol 12-myristate 13-acetate ( PMA ) /ionomycin induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC