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IFNG — IRF2

Text-mined interactions from Literome

Paludan et al., Scand J Immunol 1999 (Herpes Simplex) : Furthermore, IL-4 substantially augmented the IFN-gamma induced expression of IRF-2 , which is known to compete with IRF-1 for the DNA recognition site, ISRE ( interferon stimulated response element )
Kano et al., Biochem Biophys Res Commun 1999 : Taken together, IRF-1 mediates IFN-gamma signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis
Green et al., Leukemia 1999 (Chromosome Deletion...) : Unexpectedly, all primary acute promyelocytic leukemia ( APL ) samples lacked IRF-1 protein and most exhibited accelerated exon skipping ; furthermore, IRF-1 could not be induced by IFNgamma or all-trans retinoic acid ( ATRA ) which both induce IRF-1 in the NB4 APL cell line
Jarosinski et al., J Neuroimmunol 2002 : MHC class I gene promoter activity in astrocytes was controlled entirely through a single enhancer, the MHC-IRF-E , to which IRF-1 bound in response to IFN-gamma in wild type but not in IRF-1 ( -/- ) mouse astrocytes
Elser et al., Immunity 2002 : IRF-1 and IRF-2 induced by IFN-gamma bind to three distinct IL-4 promoter sites and function as transcriptional repressors
Tasheva et al., Molecular vision 2003 : RT-PCR analyses demonstrate that IFN-gamma rapidly and transiently suppresses mimecan expression and induces IRF-1 and IRF-2 mRNAs in bovine corneal keratocytes
Yim et al., J Interferon Cytokine Res 2003 (Breast Neoplasms...) : The role of interferon regulatory factor-1 and interferon regulatory factor-2 in IFN-gamma growth inhibition of human breast carcinoma cell lines ... Interferon (IFN) regulatory factor-1 ( IRF-1 ) and IRF-2 play opposing roles in the regulation of many IFN-gamma-inducible genes
Sheikh et al., Cardiovasc Res 2005 (Arteriosclerosis) : Northern blotting showed that lysoPC transiently and dose-dependently inhibited the IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48, interferon regulatory factor-1 and guanidine binding protein-1
Piskurich et al., Mol Immunol 2006 : DNA binding of IRF-1 and IRF-2 , members of the IFN regulatory factor family, was up-regulated in B cells in response to IFN-gamma and increased the activity of CIITA pIV
Connett et al., J Interferon Cytokine Res 2005 (Breast Neoplasms...) : The antitumor activity of IFN-gamma is mediated in part through IFN regulatory factor-1 (IRF-1) and may be blocked by IRF-2
Shi et al., Int J Biochem Cell Biol 2006 (Breast Neoplasms...) : Both treatments induced USF-1 and IRF binding complexes to promoter IV but only IFNgamma induced the binding of 435-Lung2 nuclear proteins to an ARE-1 site at the promoter III
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Buckley et al., Mol Cancer Res 2007 : Using an Affymetrix U95A microarray, IRF-7 was identified as a BRCA1 transcriptional target and was also shown to be synergistically up-regulated by BRCA1 specifically in the presence of IFN-gamma , coincident with the synergistic induction of apoptosis
Schedel et al., Am J Respir Crit Care Med 2008 (Genetic Predisposition to Disease...) : Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding, IRF-1 gene expression, and IFN-gamma regulation
Wang et al., Cancer Res 2008 (Esophageal Neoplasms) : Taken together, our results disclosed a new IRF-2 mediated inhibitory mechanism for IFN-gamma induced pathway in esophageal cancer cells : IFN-gamma induced IRF-2 up-regulation, then up-regulated IRF-2 decreased endogenous IFNGR1 level, and finally, the loss of IFNGR1 turned to enhance the resistance of esophageal cancer cells to IFN-gamma
Shultz et al., J Interferon Cytokine Res 2009 : Roles of IKK-beta, IRF1 , and p65 in the activation of chemokine genes by interferon-gamma
Sharf et al., J Biol Chem 1997 : Tyr phosphorylated ICSBP and IRF-2 are detected in expressing cells constitutively, and Tyr phosphorylated IRF-1 is induced by IFN-gamma
Faure et al., J Biol Chem 1999 : The decrease of LPS/IFN-gamma induced IRF-1 promoter activity, IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds