UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

IGF1 — PDPK1

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: PDPK1 → IGF1 (increases, IGF1 Activity) Rena et al., EMBO J 2002
Evidence: IGF-1 stimulates the phosphorylation of Thr24, Ser256, Ser319, Ser322 and Ser325 in embryonic stem (ES) cells, but not in PDK1-/- ES cells, providing genetic evidence that PDK1 (the upstream activator of PKB) is required for the phosphorylation of FKHR in mammalian cells.