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IGF1 — SIRPA

Text-mined interactions from Literome

Maile et al., J Biol Chem 2002 : IGF-I stimulated SHPS-1 phosphorylation and the subsequent recruitment of SHP-2 ... These studies indicate that IGF-IR stimulates phosphorylation of SHPS-1 which is critical for SHP-2 recruitment to the plasma membrane and for its recruitment to the IGF-IR
Maile et al., Mol Biol Cell 2003 : SHPS-1 is phosphorylated in response to IGF-I , leading to recruitment of Src homology 2 domain tyrosine phosphatase ( SHP-2 ) ... We undertook these studies to determine whether this interaction controlled SHPS-1 phosphorylation and/or SHP-2 recruitment and thereby regulated IGF-I signaling ... Disruption of IAP-SHPS-1 binding, by using an IAP monoclonal antibody or cells expressing mutant forms of IAP that did not bind to SHPS-1, inhibited IGF-I stimulated SHPS-1 phosphorylation and SHP-2 recruitment
Lieskovska et al., J Biol Chem 2006 (MAP Kinase Signaling System) : IGF-I induced both Src/SHP-2 and Src/SHPS-1 association ... IGF-I induced association of Src and SHPS-1 was also impaired in SHP-2Delata10 expressing cells, although SHP-2/SHPS-1 association was unaffected
Shen et al., Mol Cell Proteomics 2009 (Hyperglycemia) : The main aim of the present study was to identify novel proteins that interacted with the cytoplasmic domain of SHPS-1 ( SHPS-1/CD ) in response to IGF-I stimulation and define the role of these interactions in mediating specific biological functions ... Although the binding of most of these proteins to SHPS-1 was positively regulated by IGF-I, a few were negatively regulated, suggesting differential regulation of protein complexes assembled on SHPS-1/CD in response to IGF-I ... The results emphasize the importance of formation of SHPS-1 signaling complex induced by IGF-I and provide novel insights into our knowledge of the role of this molecular scaffold in regulation of IGF-I stimulated signal transduction and biological actions
Radhakrishnan et al., J Biol Chem 2010 (MAP Kinase Signaling System) : These cultures showed reduced SHPS-1 phosphorylation, transfer of SHP-2 to SHPS-1, and impaired Shc and MAPK phosphorylation and cell proliferation in response to IGF-I
Shen et al., Cell Mol Life Sci 2010 (MAP Kinase Signaling System) : In vascular smooth muscle cells, IGF-I stimulates SHPS-1/SHP2/Src complex formation which is required for IGF-I stimulated cell proliferation ... In vascular smooth muscle cells, IGF-I stimulates SHPS-1/SHP2/Src complex formation which is required for IGF-I stimulated cell proliferation
Xi et al., Endocrinology 2010 (Hyperglycemia) : Mechanistic studies showed that knockdown of p66shc enhanced IGF-I stimulated SHPS-1/p85 , p85/SHP-2, and p85/Grb2 association, all of which are required for PI-3 kinase/AKT activation
Maile et al., Diabetologia 2012 (Diabetic Retinopathy...) : Here we sought to : ( 1 ) determine whether the regulation of IGF-I responsiveness by the association of IAP with SHPS-1 is a generalised response of endothelial cells ; ( 2 ) identify the mechanism by which this association contributes to changes in endothelial cell responses to IGF-I ; and ( 3 ) determine whether inhibition of this association alters pathophysiological changes occurring in vivo