◀ Back to IRF6
CREB1 — IRF6
Text-mined interactions from Literome
Kim et al., Brain Res 2000
(Glioma) :
LPS transiently
increased the phosphorylation of p38-MAPK and
CREB ... Furthermore,
LPS plus CHX
enhanced phosphorylation of ERK, p38, and
CREB in a synergistic manner
Cho et al., Glia 2001
:
On the other hand, NAMDA increased intracellular cAMP levels and potentiated
LPS induced phosphorylated
cAMP-responsive element binding protein ( pCREB ) expression
Buzas et al., Glia 2002
:
We observed
CREB phosphorylation in
response to
LPS , which was also prevented by SB202190 and PD98059
Simi et al., J Neurochem 2005
:
We found that ( 1 ) LPS induced c-fos mRNA levels were sensitive to p38 mitogen activated protein kinase ( MAPK ) inhibitors but not to mitogen-activated/extracellular signal regulated kinase ( ERK ) or calcium-calmodulin dependent kinase inhibitors, ( 2 ) LPS activated both serum response element ( SRE ) and cyclic AMP/calcium response element ( CRE ) -driven luciferase reporters in transient transfection assays, ( 3 )
LPS induced the phosphorylation of Elk1 CRE binding protein ( CREB ) /activated transcription factor-1 (ATF-1) and the activation of GAL4-Elk1 and
GAL4-CREB chimeric proteins, and ( 4 ) mutation of both SRE and CRE elements was necessary and sufficient to completely abolish LPS induction of a rat c-fos proximal promoter-luciferase reporter
Sheu et al., Food Chem Toxicol 2006
(Glomerulonephritis) :
Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein (
CREB )
induced by
LPS/IFN-gamma
Woo et al., Immunobiology 2006
:
Baicalein and baicalin had no effect on
LPS induced nuclear factor-kappaB (NF-kappaB) and cAMP response element binding protein (
CREB ) DNA binding activity
Uto et al., Oncol Rep 2007
:
LPS induced activation of all of these factors and 6-MITC
suppressed LPS induced activation of AP-1, C/EBPdelta,
CREB , but not NF-kappaB
Choi et al., Br J Pharmacol 2009
(MAP Kinase Signaling System) :
In addition, the inhibitory effect of torilin on NF-kappaB and CREB was shown by torilin mediated recovery of
LPS induced degradation of inhibitor kappaB-alpha and suppression of LPS induced phosphorylation of
CREB respectively
Cho et al., Inflamm Res 2009
:
Immunoblot, gel-shift, and chromatin-immunoprecipitation assays showed the
activation of
CREB by
LPS , and the ability of H89 to inhibit it, suggesting that H89 's inhibition of CREB may affect MKP-1 induction
Dai et al., PloS one 2011
(MAP Kinase Signaling System) :
In addition, gastrodin blocked
LPS induced phosphorylation of inhibitor ?B-a ( I?B-a ) ( and hence the activation of NF-?B ) and of
CREB , respectively
Moon et al., Exp Cell Res 2011
:
cAMP production and
CREB ( S133 ) phosphorylation were
augmented by
LPS-stimulation
Caruso et al., Mol Cell Endocrinol 2012
:
Although both a-MSH and
LPS+IFN-? increased cAMP responding element binding protein (
CREB ) activation, LPS+IFN-? did not modify BDNF expression