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FPR2 — IRF6
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Le et al., J Immunol 2004
:
Functional
FPR2 was
induced by bacterial
LPS in murine microglial cells, the resident phagocytic cells that play a pivotal role in inflammatory and immunological diseases in the CNS ... These effects of TGF-beta1 culminate in the inhibition of
LPS induced activation of NF-kappaB and the
up-regulation of
FPR2 in microglial cells
Mandal et al., J Immunol 2005
:
In this study, we show that
LPS can markedly
enhance the expression of the
formyl peptide receptor gene ( FPR1 ) in mouse macrophages and neutrophils by enhancing transcription and by stabilization of the mRNA