◀ Back to MAP3K7

MAP3K7 — TAB3

Pathways - manually collected, often from reviews:

• KEGG NOD-like receptor signaling pathway: RIPK2 → Complex of MAP3K7-TAB1-TAB2-TAB3 (protein-protein, activation)
  
• KEGG NOD-like receptor signaling pathway: Complex of MAP3K7-TAB1-TAB2-TAB3 → Complex of CHUK-IKBKB-IKBKG (protein-protein, activation)
  
• KEGG NOD-like receptor signaling pathway: Complex of MAP3K7-TAB1-TAB2-TAB3 → MAPK1/MAPK3 (protein-protein, activation)
• KEGG NOD-like receptor signaling pathway: Complex of MAP3K7-TAB1-TAB2-TAB3 → MAPK10/MAPK8/MAPK9 (protein-protein, activation)
• KEGG NOD-like receptor signaling pathway: Complex of MAP3K7-TAB1-TAB2-TAB3 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, activation)
  
• Reactome Reaction: MAP3K7 → TAB3 (reaction) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Ono et al., J Biol Chem 2001, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Adhikari et al., Oncogene 2007, Shibuya et al., Science 1996
• Reactome Reaction: MAP3K7 → TAB3 (direct_complex) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Ono et al., J Biol Chem 2001, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Adhikari et al., Oncogene 2007, Shibuya et al., Science 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TAB3 — MAP3K7 (physical association, affinity chromatography technology) Criollo et al., EMBO J 2011
• IRef Biogrid Interaction: TAB3 — MAP3K7 (direct interaction, pull down) Mendoza et al., Biochem J 2008*
• IRef Biogrid Interaction: TAB3 — MAP3K7 (physical association, affinity chromatography technology) Hong et al., Nat Immunol 2007
• IRef Biogrid Interaction: TAB3 — MAP3K7 (physical association, affinity chromatography technology) Minoda et al., Biochem Biophys Res Commun 2009*
• IRef Biogrid Interaction: TAB3 — MAP3K7 (physical association, affinity chromatography technology) Cheung et al., Biochem J 2004*
• IRef Biogrid Interaction: TAB3 — MAP3K7 (physical association, affinity chromatography technology) Ishitani et al., EMBO J 2003
• IRef Biogrid Interaction: TAB3 — MAP3K7 (physical association, affinity chromatography technology) Li et al., Immunity 2011
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 7: TNF-alpha/NF-kappa B signaling complex 7 complex (CDC37-FKBP5-HSP90AA1-HSP90AB1-MAP3K7-TAB1-TAB2-TAB3) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of HSP90AA1-MAP3K7-TAB1-CDC37-FKBP5-HSP90AB1-TAB3-TAB2 (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 57 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: Complex of TAB3-TRAF6-MAP3K7 (association, anti tag coimmunoprecipitation) Jiang et al., J Biol Chem 2003
• IRef Intact Interaction: Complex of TAB1-MAP3K7-TAB3-TAB2-TAB3-MAP3K7-TAB2-TAB1 (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of BECN1-MAP3K7-TAB3 (association, anti bait coimmunoprecipitation) Criollo et al., EMBO J 2011
• IRef Intact Interaction: TAB3 — MAP3K7 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: TAB3 — MAP3K7 (physical association, anti bait coimmunoprecipitation) Criollo et al., EMBO J 2011
• IRef Ophid Interaction: TAB3 — MAP3K7 (aggregation, confirmational text mining) Bouwmeester et al., Nat Cell Biol 2004
• IRef Ophid Interaction: TAB3 — MAP3K7 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Cheung et al., Biochem J 2004 : The SAPK2a/p38alpha mediated phosphorylation of TAB2 and TAB3 may contribute to the SAPK2a/p38alpha mediated feedback control of TAK1 activity that also involves the phosphorylation of TAB1
Besse et al., J Biol Chem 2007 : TAK1 dependent signaling requires functional interaction with TAB2/TAB3
Prickett et al., J Biol Chem 2008 : TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB ... Recombinant GST-TAB4 bound in an overlay assay directly to inactive TAK1 and activated TAK1 but not TAK1 phosphorylated in the linker sites, suggesting a bind and release mechanism