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LEP — TIMP1
Text-mined interactions from Literome
Park et al., Exp Mol Med 2001
(Arteriosclerosis...) :
Leptin also
induced increases of MMP-2, MMP-9,
TIMP-1 , and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Cao et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
The capacity of
leptin to
induce TIMP-1 and its signaling molecules were investigated in a human HSC cell line, LX-2
Cao et al., Liver Int 2006
:
DLPC and SAMe combined prevent
leptin stimulated
TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction ... These treatments also suppressed
leptin stimulated
TIMP-1 promoter activity and decreased TIMP-1 mRNA stability, contributing to TIMP-1 mRNA down-regulation
Lin et al., Mol Endocrinol 2006
:
Site directed mutagenesis for Sp1 reduced the enhancing
effect of
leptin on
TIMP-1 transcriptional activation, and this effect was dose dependent on the number of Sp1 sites mutated ... We propose a novel mechanism whereby
leptin mediated
TIMP-1 transcription employs a Sp1/pSTAT3 dependent mechanism, one of which is a noncanonical association between Sp1 and pSTAT3
Choudhury et al., Metabolism 2006
:
At these concentrations,
leptin does not
affect MMP-1 or
TIMP-1 expression or collagenolytic activity of HSC
Li et al., Eur J Pharmacol 2008
:
Suppressive effects of leflunomide on
leptin induced
TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis ... Pretreatment with A771726 ( alpha, alpha, alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide ), leflunomide 's metabolite, fully prevented
leptin induced
TIMP-1 production in HSCs