◀ Back to MAPK14
MAPK14 — PLA2G1B
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Degousee et al., J Biol Chem 2001
:
These results provide direct evidence that p38
MAPK activation was
necessary for interleukin-1beta induced synthesis and release of GIIa
PLA(2) by cardiomyocytes
Xu et al., J Neurochem 2002
(MAP Kinase Signaling System) :
Role of PKC and
MAPK in cytosolic
PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes
Slomiany et al., J Physiol Pharmacol 2003
:
We concluded that LPS interferes with
MAPK dependent activation of cytosolic
PLA(2) since MAPKs immunoprecipitate added to the LPS-cytosol restored activation of cytosolic PLA(2)-specific fusion of the Golgi transport vesicles with apical mucosal cell membrane
Araki et al., Free Radic Biol Med 2005
:
PLA2 , COX, PKC, NADH dehydrogenase, and XO inhibitors
prevented the CA-induced ROS generation but not ERK 1/2, PI 3 K, p38
MAPK , and MLCK inhibitors
Hendrickx et al., Biochem Biophys Res Commun 2005
(Neovascularization, Pathologic) :
PLA2 inhibition significantly protects cells from the PDT induced intrinsic apoptosis and
attenuates the activation of p38
MAPK , a survival signal mediating the up-regulation of cyclooxygenase-2 that converts arachidonic acid into prostanoids
Wang et al., Cardiovasc Res 2010
(Atherosclerosis) :
Inhibition of either PI3K or p38
MAPK completely
blocked oxLDL induced
lp-PLA2 expression
Chen et al., J Cell Biochem 2010
(Leukemia) :
Transfection ASK1 siRNA and overexpression of dominant negative p38alpha MAPK proved that ASK1 pathway was responsible for
PLA(2) induced p38
MAPK and JNK activation and p38alpha MAPK activation suppressed dynamically persistent JNK activation
Liu et al., J Cell Biochem 2010
(Neuroblastoma) :
PLA(2) treatment
induced p38
MAPK activation and ERK inactivation
Chatterjee et al., J Biol Chem 2011
:
Phosphorylation as well as
PLA(2) activity and ROS generation were markedly
reduced by the
MAPK inhibitor, U0126
Wuhanqimuge et al., FEBS open bio 2013
:
Exogenously added secretory
PLA2 ( sPLA2 )
enhanced NGF induced
MAPK phosphorylation at a comparable level to LPC, suggesting that LPC generated in situ by sPLA2 mediated hydrolysis of membrane PC stimulated NGF-TrkA signal
Sugiura et al., FEBS Lett 1995
:
Group II
PLA2 ( 1-15 U/ml ) rapidly
activated mitogen activated protein ( MAP ) kinase
Hashizume et al., J Biochem 1997
:
Sphingosine
increased cytosolic
PLA2 activity in response to U46619 with enhancement of
mitogen activated protein kinase activity
Dulin et al., Proc Natl Acad Sci U S A 1998
:
Phospholipase A2-mediated activation of
mitogen activated protein kinase by angiotensin II ... Inhibition of
PLA2 by mepacrine
diminished both AA release and
MAPK phosphorylation, induced by Ang II