◀ Back to IFNG

CISH — IFNG

Text-mined interactions from Literome

Crespo et al., Eur J Immunol 2002 (MAP Kinase Signaling System) : In this regard, we demonstrate that overexpression of either SOCS protein suppresses induction of the mouse inducible nitric oxide synthase (iNOS) gene promoter : apparently by suppressing interactions between Stat1 alpha and IFN-gamma activated sites present in both the iNOS, and interferon regulatory factor-1, gene promoters
Turnley et al., J Neuroimmunol 2002 : This study shows that sensory neurons but not glia constitutively express high levels of suppressor of cytokine signaling-1 ( SOCS1 ), a negative regulator of IFNgamma signaling
Federici et al., J Immunol 2002 (Dermatitis, Allergic Contact...) : Suppressor of cytokine signaling (SOCS)1 and SOCS3 are negative regulators of IFN-gamma signaling and are induced in many cell types by IFN-gamma itself or by other cytokines ... We show in this work that SOCS1, SOCS2 , SOCS3, and cytokine-inducible SH2 containing protein mRNA were up-regulated by IFN-gamma in normal human keratinocytes, whereas only SOCS1 or SOCS1 and cytokine-inducible SH2 containing protein were induced by TNF-alpha or IL-4, respectively
Nakayama et al., Nucleic acids research. Supplement (2001) 2001 : Expression of IFN gamma gene is regulated by either DNA-methylation or cis-elements of transcriptional factors such as AP-1, NFAT, AP-4, YY-1, ATF and GATA
Stark et al., J Neuroimmunol 2004 (Encephalomyelitis, Autoimmune, Experimental) : These findings suggest a role for IFN-g induced SOCS expression in regulation of CNS inflammatory responses by astrocytes
Truchet et al., Biol Reprod 2004 : In parallel, we showed that the transcription of two IFNgamma-target genes, namely interferon regulatory factor-1 (IRF-1) and suppressor of cytokine signaling-1 ( SOCS-1 ) is indeed increased in two-cell embryos in response to IFNgamma
Yu et al., J Immunol 2004 : We further show that STAT1 signals play major roles in inducing SOCS expression in Th cells and that induction of SOCS expression by IL-4, IL-12, or IFN-gamma is compromised in STAT1-deficient primary Th cells
Qing et al., J Biol Chem 2005 : Suppressor of cytokine signaling (SOCS)-1 , the key negative regulator of interferon (IFN)-gamma dependent signaling, is induced in response to IFNgamma
Ramana et al., Biochem Biophys Res Commun 2005 (Adenocarcinoma...) : Using microarray technology, we previously demonstrated that IFN-gamma induces suppressor of cytokine signaling-3 ( SOCS-3 ) in Stat1-/- mouse embryonic fibroblasts and bone marrow derived macrophages
Osna et al., Hepatology 2005 : In addition, SOCS1 , a negative regulator of IFNgamma signaling and which is degraded by the proteasome, was stabilized by ethanol treatment, presumably because of inhibited proteasome activity
Emery et al., Neuroscience 2006 (Disease Models, Animal...) : It is found that leukemia inhibitory factor rapidly and strongly induces the expression of suppressors of cytokine signaling-3 in cultured rat oligodendrocytes, whereas interferon-gamma weakly induces the expression of both suppressor of cytokine signaling-1 and 3
Monsalve et al., J Immunol 2006 (Inflammation) : Furthermore, Raw 264.7 Notch-IC stable transfectants increased STAT1 dependent transcription in response to IFN-gamma , leading to higher expression of IFN regulatory factor-1, suppressor of cytokine signaling-1 , ICAM-1, and MHC class II proteins
Dawson et al., BMC immunology 2006 : Stimulation of human PBMCs and purified T cells with ATRA and 9-cis-RA increased mRNA and protein levels of IL-4, IL-5, and IL-13 and decreased levels of IFN-gamma , IL-2, IL-12p70 and TNF-alpha upon activation with anti-CD3 and/or anti-CD28 mAbs
Madonna et al., FASEB J 2008 : Here we show that, after IFN-gamma stimulation, SOCS1 inhibited IFN-gamma receptor and STAT1 phosphorylation but maintained ERK1/2 activation
Letourneur et al., Mol Immunol 2009 : Sp2 regulates interferon-gamma mediated socs1 gene expression ... Interferon (IFN)-gamma induces the expression of the socs1 gene in several cell types through several cis elements present in its promoter and their binding proteins
Madonna et al., J Immunol 2010 (Psoriasis) : We explored the regulatory mechanisms involved in socs1 gene transcription, and found that Sp1 and IFN regulatory factor-1 transcription factors are, respectively, responsible for the basal and IFN-gamma induced activity of human socs1 promoter
Cantorna et al., J Immunol 1996 : All-trans-, 9-cis- , and 13-cis-retinoic acid, and the synthetic retinoid Ch55, inhibited IFN-gamma synthesis effectively, whereas retinaldehyde, retinol, and retinyl acetate did not
Eklund et al., J Immunol 1996 : Three cis-elements located between -450 and -100 bp of the gp91-phox promoter are required for IFN-gamma induced transcription
Suzuki et al., Oncogene 1998 (Leukemia, Myeloid, Acute) : In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)