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MDM2 — NEDD8
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Singh et al., J Biol Chem 2007
:
Furthermore, we show that, similar to Mdm2, the
Mdm2-MdmX complex has Nedd8 ligase activity and that all mutations that affect the ubiquitin ligase activity of Mdm2 also
affect its
Nedd8 ligase activity
Dohmesen et al., Cell cycle (Georgetown, Tex.) 2008
:
We found that Tip60 is capable of selectively inhibiting the
Mdm2 mediated conjugation of
Nedd8 to p53, whereas it did not affect p53 ubiquitination