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HSPG2 — RNPEP

Text-mined interactions from Literome

Chen et al., Kidney Int 2002 (Amyloidosis...) : U73122 [ phospholipase C (PLC) inhibitor ] or 2-APB [ specific inhibitor of inositol 1,4,5-trisphosphate ( IP3 ) -induced [ Ca2+ ] i release ] completely blocked the beta2m induced increase in [ Ca2+ ] i and the up-regulation of VCAM-1 and COX-2
Wu et al., Pflugers Arch 2004 (Calcium Signaling) : In addition, 100 microM 2-APB significantly inhibited ACh induced phospholipase C (PLC) activation
Suriyo et al., Toxicol In Vitro 2012 : Pretreatment with U-73122 ( a specific PLC inhibitor ) or 2-APB ( a specific IP3 receptor antagonist ) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite induced elevation of [Ca2+ ] i. Cytotoxic concentrations of arsenite ( 5 and 10 µM ) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide ( NO ) production and apoptosis after 24-h exposure