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CCND1 — RHO
Text-mined interactions from Literome
Lee et al., Mol Cell Biol 2000
(Cell Transformation, Neoplastic...) :
Induction of
cyclin D1 by NeuT
involved Ras, Rac,
Rho , extracellular signal regulated kinase, c-Jun N-terminal kinase, and p38, but not phosphatidylinositol 3-kinase
Liberto et al., Oncogene 2002
:
Rho regulates p21 ( CIP1 ),
cyclin D1 , and checkpoint control in mammary epithelial cells ... Our results demonstrate that Rho plays a fundamental role in promoting Ras dependent S phase entry in mammary epithelial cells, whether in response to normal or oncogenic signaling, and indicate that in cells expressing oncogenic Ras, the activation of
Rho diminishes p21 ( CIP1 ) expression,
increases cyclin D1 promoter activity, and uncouples DNA synthesis from mitosis
Roovers et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling, but only
Rho kinase inhibition
allowed for the induction of
cyclin D1 and activation of cdk4 via Rac/Cdc42 ... Overall, our results indicate that
Rho kinase dependent stress fiber formation is
required for sustained activation of the MEK/ERK pathway and the mid-G ( 1 ) phase induction of
cyclin D1 , but not for other aspects of cdk4 or cdk2 activation
Roovers et al., Dev Cell 2003
:
Nuclear translocation of LIM kinase mediates
Rho-Rho kinase
regulation of
cyclin D1 expression
Swant et al., J Biol Chem 2005
(Cell Transformation, Neoplastic...) :
Rho GTPase dependent signaling is
required for macrophage migration inhibitory factor mediated expression of
cyclin D1
Sterpetti et al., Am J Physiol Gastrointest Liver Physiol 2006
(Carcinoma, Hepatocellular...) :
Lbc stably transfected hepatocarcinoma cells exhibit increased proliferation and levels of ERK and
cyclin D1 activation, which are
blocked by a
Rho inhibitor
Morikawa-Futamatsu et al., Life Sci 2006
(Adenoviridae Infections...) :
HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via
Rho kinase and
inhibition of
cyclin D1 ... Specific
Rho kinase inhibitor, Y-27632 inhibited angiotensin II-induced cardiomyocyte hypertrophy and
increased cyclin D1
Watts et al., Respir Res 2006
(Pulmonary Fibrosis) :
This potentially unravels new molecular targets for future anti-IPF strategies ; accordingly, Simvastatin inhibition of
Rho mediated
cyclin D1 expression in IPF fibroblasts merits further exploitation
Cerezo et al., Mol Cell Biol 2009
(Cell Transformation, Neoplastic) :
Restoring
Rho activity, which is downregulated after loss of Cav1, antagonizes Rac1 and
prevents cyclin D1 accumulation after serum starvation or loss of adhesion
Nie et al., EMBO Rep 2009
:
Our data thus indicate that GEF-H1 and ZONAB form a signalling module that mediates
Rho regulated
cyclin D1 promoter activation and expression