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Zhang et al., Mol Cell Biol 2007
:
Nkd inhibits Wnt signaling by binding the intracellular protein Dishevelled ( Dsh )
Van Raay et al., Dev Biol 2007
:
Overexpression of Nkd1 or Nkd2a suppressed canonical Wnt/beta-catenin signaling at multiple stages of early zebrafish development and also exacerbated the cyclopia and axial mesendoderm convergence and extension ( C & E ) defect in the non-canonical Wnt/PCP mutant silberblick ( slb/wnt11 ) ... Reducing Nkd function using antisense morpholino oligonucleotides resulted in increased expression of canonical Wnt/beta-catenin target genes
Chan et al., Dev Biol 2008
:
Nkd is an intracellular protein that is composed of separable membrane- and nuclear-localization sequences ( NLS ) as well as a conserved EF-hand motif that binds the Wnt receptor associated scaffold protein Dishevelled ( Dsh ), but the mechanism by which Nkd inhibits Wnt signaling remains a mystery
Hu et al., Molecular cancer 2010
(Neoplasms) :
Down-regulation of NKD2 causes Wnt activation and TGFa misdelivery, suggesting its functions in cell homeostasis and prevention of tumorigenesis
Cao et al., Monoclonal antibodies in immunodiagnosis and immunotherapy 2013
(Colorectal Neoplasms) :
Naked2 (NKD2) is a member of the Naked family and negatively regulates canonical Wnt signaling