Gene interactions and pathways from curated databases and text-mining

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IL10 — MYLIP

Text-mined interactions from Literome

Stanczyk et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid) : Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta , lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
McCoy et al., J Biol Chem 2010 : IL-10 inhibits miR-155 induction by toll-like receptors ... Analyzing microRNAs known to be induced by TLR4, we found that IL-10 could inhibit the expression of miR-155 in response to lipopolysaccharide but had no effect on miR-21 or miR-146a ... This inhibitory effect of IL-10 on miR-155 led to an increase in the expression of the miR-155 target, SHIP1
Majid et al., Cancer 2010 (Neoplasm Invasiveness...) : In this study, the authors demonstrated that miRNA-205 (miR-205) induced the expression the interleukin ( IL ) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters
Monk et al., PloS one 2010 (MAP Kinase Signaling System) : In addition the anti-inflammatory cytokine IL-10 was found to be able to induce miR-146a and b, but inhibited miR-155 induction
Liu et al., FEBS Lett 2011 : Overexpression of miR-98 inhibited TLR4 triggered IL-10 production and promoted COX-2 expression
Gaziel-Sovran et al., Cancer Cell 2011 (Disease Progression...) : Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10 , and reduced immune cell activation and recruitment
Krishnamoorthy et al., Am J Pathol 2012 (Acute Disease...) : Overexpression of miR-208a in human macrophages up-regulated IL-10
Sharma et al., J Appl Physiol 2012 (Asthma...) : We recently demonstrated that miR-106a inhibits IL-10 in a post-transcriptional manner
Wu et al., J Lipid Res 2012 (Hyperlipidemias) : Abundance of miR-181a attenuated ox-LDL induced CD83 and CD40 expression, inhibited the secretion of interleukin (IL)-6 and TNF-a, and up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL
Li et al., Cell Mol Immunol 2012 : A previous study showed that miR-466l upregulates IL-10 expression in macrophages by antagonizing RNA binding protein tristetraprolin mediated IL-10 mRNA degradation
Hutchison et al., Glia 2013 : Knockdown of miR-181 enhanced LPS induced production of pro-inflammatory cytokines ( TNF-a, IL-6, IL-1ß, IL-8 ) and HMGB1, while overexpression of miR-181 resulted in a significant increase in the expression of the anti-inflammatory cytokine IL-10
Cheung et al., PloS one 2013 : Therefore, we examined the mechanism by which IL-10 inhibits miR-155 ... This inhibitory effect of IL-10 on miR-155 expression involved the contribution of both the STAT3 transcription factor and the phosphoinositol phosphatase SHIP1