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IL10 — MYLIP
Text-mined interactions from Literome
Stanczyk et al., Arthritis Rheum 2008
(Arthritis, Rheumatoid) :
Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of
miR-155 could be further
induced by TNFalpha,
interleukin-1beta , lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
McCoy et al., J Biol Chem 2010
:
IL-10 inhibits
miR-155 induction by toll-like receptors ... Analyzing microRNAs known to be induced by TLR4, we found that
IL-10 could
inhibit the expression of
miR-155 in response to lipopolysaccharide but had no effect on miR-21 or miR-146a ... This inhibitory
effect of
IL-10 on
miR-155 led to an increase in the expression of the miR-155 target, SHIP1
Majid et al., Cancer 2010
(Neoplasm Invasiveness...) :
In this study, the authors demonstrated that
miRNA-205 (miR-205) induced the expression the
interleukin ( IL ) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters
Monk et al., PloS one 2010
(MAP Kinase Signaling System) :
In addition the anti-inflammatory cytokine
IL-10 was found to be able to induce miR-146a and b, but
inhibited miR-155 induction
Liu et al., FEBS Lett 2011
:
Overexpression of
miR-98 inhibited TLR4 triggered
IL-10 production and promoted COX-2 expression
Gaziel-Sovran et al., Cancer Cell 2011
(Disease Progression...) :
Ectopic expression of
miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7,
resulted in increased synthesis of the immunosuppressive cytokine
IL-10 , and reduced immune cell activation and recruitment
Krishnamoorthy et al., Am J Pathol 2012
(Acute Disease...) :
Overexpression of
miR-208a in human macrophages
up-regulated IL-10
Sharma et al., J Appl Physiol 2012
(Asthma...) :
We recently demonstrated that
miR-106a inhibits
IL-10 in a post-transcriptional manner
Wu et al., J Lipid Res 2012
(Hyperlipidemias) :
Abundance of
miR-181a attenuated ox-LDL induced CD83 and CD40 expression, inhibited the secretion of interleukin (IL)-6 and TNF-a, and
up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL
Li et al., Cell Mol Immunol 2012
:
A previous study showed that
miR-466l upregulates
IL-10 expression in macrophages by antagonizing RNA binding protein tristetraprolin mediated IL-10 mRNA degradation
Hutchison et al., Glia 2013
:
Knockdown of miR-181 enhanced LPS induced production of pro-inflammatory cytokines ( TNF-a, IL-6, IL-1ß, IL-8 ) and HMGB1, while overexpression of
miR-181 resulted in a significant increase in the expression of the anti-inflammatory cytokine
IL-10
Cheung et al., PloS one 2013
:
Therefore, we examined the mechanism by which
IL-10 inhibits
miR-155 ... This inhibitory
effect of
IL-10 on
miR-155 expression involved the contribution of both the STAT3 transcription factor and the phosphoinositol phosphatase SHIP1