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CD40LG — PTGS2

Text-mined interactions from Literome

Garlichs et al., Atherosclerosis 2002 (Inflammation) : The hypothesis was tested that CD40-CD154 interaction is involved in the induction of cyclooxygenase-2 and the release of prostanoids in human endothelial cells
Dongari-Bagtzoglou et al., Inflamm Res 2003 : To investigate whether CD40-CD154 interactions on HUVEC can trigger COX-2 synthesis as well as PGE2 and PGI2 secretion in vitro and explore whether the CD40 triggered prostanoids provide costimulatory signals for IL-6 secretion in this cell type
Mosheimer et al., Blood Coagul Fibrinolysis 2005 (Arteriosclerosis) : CD40-ligand dependent induction of COX-2 gene expression in endothelial cells by activated platelets : inhibitory effects of atorvastatin
Futagami et al., Prostaglandins Leukot Essent Fatty Acids 2008 (Stomach Neoplasms) : COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells ... The aim of this study was to examine the effect of MCP-1/CCR2 and CD40-CD40L interaction on COX-2 and VEGF expression in endothelial cells ... CD40-CD40L interaction induced COX-2 production and subsequently, upregulated COX-2 production contributed to elevated VEGF and CCR2 levels in CD40L stimulated HUVECs
Futagami et al., J Gastroenterol 2008 (Adenocarcinoma...) : MCP-1 and CD40L had a synergistic effect on COX-2 expression and subsequent VEGF production in gastric cancer