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DVL3 — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rosso et al., Nat Neurosci 2005
:
In contrast, Wnt7b and
Dvl activate
Rac and JNK in hippocampal neurons
Esufali et al., Cancer Res 2007
(Colorectal Neoplasms) :
In agreement,
Dvl-3 but not beta-catenin
caused increased activation of
Rac1b levels, which may explain the functional cooperativity displayed in transcription assays
Nishita et al., Mol Cell Biol 2010
:
We further show that polymerized
Dvl is colocalized with Rac1 and that suppressed expression of
Rac1 inhibits Wnt5a induced AP-1 activation
Čajánek et al., Mol Cell Biol 2013
(Wnt Signaling Pathway) :
Next, we show that Tiam1, a Rac1 guanosine exchange factor (GEF), is expressed in the ventral midbrain, interacts with Dvl, facilitates Dvl-Rac1 interaction, and is required for
Dvl- or Wnt5a induced
activation of
Rac1