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FYN — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by focal adhesion kinase: RAC1/GDP complex (RAC1) → FAK/Src-Yes-Fyn/p130 CAS/CRK/DOCK1/ELMO1 complex (PTK2-YES1_SRC_FYN-BCAR1-CRK-DOCK1-ELMO1) (modification, collaborate)
  Cho et al., J Cell Biol 2002, Hsia et al., J Cell Biol 2003, Sharma et al., BMC cell biology 2008, Kiyokawa et al., Genes Dev 1998, Dolfi et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Netrin-mediated signaling events: RAC1/GDP complex (RAC1) → netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) (modification, collaborate)
  Liu et al., J Neurosci 2007
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) → RAC1/GTP complex (RAC1) (modification, activates) Liu et al., J Neurosci 2007
  Evidence: mutant phenotype
• Reactome Reaction: FYN → RAC1 (indirect_complex) Zhang et al., J Cell Biol 2003, Marston et al., Nat Cell Biol 2003, Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008
• Reactome Reaction: FYN → RAC1 (reaction) Gatti et al., J Biol Chem 1999, Chong et al., J Biol Chem 2001, Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Cell Biol 2003, Marston et al., Nat Cell Biol 2003, Tolias et al., Neuron 2005, Zhang et al., J Neurosci 2005, Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008, Yoo et al., Mol Cells 2010, Crespo et al., Nature 1997, Han et al., Science 1998

Text-mined interactions from Literome

Liang et al., J Neurosci 2004 : Moreover, inhibition of integrin engagement or of Fyn activation blocked activation of Rac1 and cdc42 as well as myelin basic protein expression
Hoshina et al., Genes Cells 2007 : These results suggest that FAK/Fyn mediated activation of Rac1 and Cdc42 is critical for laminin induced outgrowth of oligodendrocyte processes