Gene interactions and pathways from curated databases and text-mining

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MMP17 — TP53

Text-mined interactions from Literome

Sun et al., Mol Carcinog 1999 (Neoplasm Metastasis) : p53 transcriptionally activates expression of the genes encoding epidermal growth factor receptor, matrix metalloproteinase (MMP)-2 , cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Patwari et al., Osteoarthritis Cartilage 2005 : Since the induction by IL-1 was not accompanied by marked changes in total ADAMTS4 protein, but rather in partial conversion of p68 to p53 and release of both from the tissue, we conclude that aggrecanolysis in this model system results from MT4-MMP mediated processing of a resident pool of ADAMTS4 and release of the p68 and p53 from their normal association with the cell surface
Xiao et al., J Cell Biochem 2009 (Melanoma) : Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate ( VC-IP ) against ultraviolet-A ray induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression