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EEF2K — PRKAA1

Pathways - manually collected, often from reviews:

• WikiPathways AMP-activated Protein Kinase (AMPK) Signaling: Complex of PRKAG3-PRKAA1-PRKAG2-PRKAG1-PRKAB2-PRKAB1-PRKAA2 → EEF2K (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: EEF2K — PRKAA1 (in vitro) Diggle et al., Biochem J 2001*, Wang et al., EMBO J 2001, Browne et al., J Biol Chem 2004*, Browne et al., Mol Cell Biol 2004*
• IRef Hprd Interaction: EEF2K — PRKAA1 (in vivo) Diggle et al., Biochem J 2001*, Wang et al., EMBO J 2001, Browne et al., J Biol Chem 2004*, Browne et al., Mol Cell Biol 2004*

Text-mined interactions from Literome

Horman et al., Curr Biol 2002 : Therefore, the activation of eEF2 kinase by AMPK , resulting in the phosphorylation and inactivation of eEF2, provides a novel mechanism for the inhibition of protein synthesis
Horman et al., J Biol Chem 2003 (Anoxia...) : Human recombinant eEF2 kinase (eEF2K) was phosphorylated by AMPK in a time- and AMP dependent fashion, and phosphorylation led to eEF2K activation, similar to that observed in extracts from ischemic hearts
Kruiswijk et al., Science signaling 2012 : Here, we show that in response to genotoxic stress, eEF2K was activated by AMPK ( adenosine monophosphate activated protein kinase ) -mediated phosphorylation on serine 398
Leprivier et al., Cell 2013 (Brain Neoplasms...) : We report that eukaryotic elongation factor 2 kinase ( eEF2K ), which is activated by AMP-kinase (AMPK) , confers cell survival under acute nutrient depletion by blocking translation elongation