◀ Back to FOXO1
CDK1 — FOXO1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FOXO1
→
Complex of CCNB1-CDK1
(decreases, CCNB1/CDK1 Activity)
Liu et al., Oncogene 2008*
Evidence: forced expression of FOXO1 causes a delay in the transition from G2 to M phase. This effect is blocked completely by overexpression of CDK1 and cyclin B1.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Intact Interaction:
Complex of FOXO1-CDK1-CCNB1
(phosphorylation reaction, protein kinase assay)
Liu et al., Oncogene 2008*
-
IRef Intact Interaction:
CDK1
—
FOXO1
(phosphorylation reaction, protein kinase assay)
Liu et al., Oncogene 2008*
-
IRef Intact Interaction:
CDK1
—
FOXO1
(physical association, anti bait coimmunoprecipitation)
Liu et al., Oncogene 2008*
-
IRef Intact Interaction:
CDK1
—
FOXO1
(direct interaction, pull down)
Liu et al., Oncogene 2008*
-
IRef Intact Interaction:
CDK1
—
FOXO1
(physical association, anti tag coimmunoprecipitation)
Liu et al., Oncogene 2008*
Text-mined interactions from Literome
Yuan et al., Science 2008
:
Activation of
FOXO1 by
Cdk1 in cycling cells and postmitotic neurons ... In proliferating cells,
Cdk1 induced
FOXO1 Ser249 phosphorylation at the G2/M phase of the cell cycle, resulting in FOXO1 dependent expression of the mitotic regulator Polo-like kinase (Plk)
Liu et al., Oncogene 2008
:
Accordingly, overexpression of
CDK1 inhibits the transcriptional activity of
FOXO1 in PCa cells through S249 phosphorylation on FOXO1