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CHUK — HDAC3
Text-mined interactions from Literome
Hoberg et al., Mol Cell Biol 2006
:
Introduction of nonphosphorylatable mutants of RelA/p65 and
SMRT proteins or the
inhibition of
IKK activity results in active repression of NF-kappaB promoters by tethering the SMRT-HDAC3 complex
Gloire et al., J Biol Chem 2007
:
Further molecular studies demonstrated that the removal of chromatin bound
HDAC3 , a histone deacetylase inhibiting p65 DNA binding, is differentially
regulated by
IKKalpha in a promoter-specific manner ... Indeed, whereas the absence of
IKKalpha induces
HDAC3 recruitment and repression on the icam-1 promoter, it has an opposite effect on the ikappabalpha promoter, where a better p65 binding occurs