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MMP1 — SMAD3

Text-mined interactions from Literome

Yuan et al., J Biol Chem 2001 : Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3 ... Smad mediated repression of MMP-1 gene expression may be important for preventing excessive matrix degradation induced by inflammatory cytokines ; disruption of Smad signaling, as occurs in certain cancer cells, may thus be causally linked to uncontrolled tissue destruction mediated through MMP-1
Lee et al., Biol Pharm Bull 2012 : These findings indicate that macelignan regulates the expression of MMP-1 and type I procollagen in UV-irradiated human skin fibroblasts by modulating MAPK and TGF-ß/Smad signaling, suggesting its potential as an efficacious antiphotoaging agent