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DEFB103B — IL4
Text-mined interactions from Literome
Nomura et al., J Immunol 2003
(Dermatitis, Atopic...) :
Because HBD-2, IL-8, and iNOS are known to be inhibited by Th2 cytokines, we examined the
effects of
IL-4 and IL-13 on
HBD-3 expression in keratinocyte culture in vitro ... We found that IL-13 and
IL-4 inhibited TNF-alpha- and IFN-gamma induced
HBD-3 production
Howell et al., Clin Immunol 2006
(Dermatitis, Atopic...) :
Furthermore, we demonstrate the down-regulatory
effect of
IL-4 , IL-10, and IL-13 - which are over expressed in the skin of AD patients - on
HBD-3 expression in keratinocytes
Howell et al., J Invest Dermatol 2008
(Acute Disease...) :
Importantly, transduction of p21-recombinant protein into keratinocytes prevented
IL-4/IL-13 mediated inhibition of FLG and
HBD-3 expression