Gene interactions and pathways from curated databases and text-mining

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IL4 — JAK1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Wery-Zennaro et al., FEBS Lett 1999 : In this study, we report that in human B cells, IL-4 caused rapid phosphorylation of Janus kinase (JAK) 1 and JAK3 tyrosine kinases ... In keratinocytes, IL-4 induced JAK1 and JAK2 phosphorylation but, unlike in immune cells, IL-4 did not involve JAK3 activation for its signaling
Haque et al., J Biol Chem 2000 : We show that the SH2 domains of SOCS-2, SOCS-3, and cytokine-inducible SH2 containing protein are functionally redundant in regulating the IL-4 dependent Jak-Stat signaling ... Thus, the Thr-Phe motif in the Pre-SH2 domain plays a critical role in SOCS-3 mediated inhibition of the IL-4 dependent Jak-Stat signaling, likely by regulating the mode of SOCS-Jak interaction
Jiang et al., J Immunol 2001 : Examination of Jak1-deficient cell lines demonstrates that Jak1 is required for the activation of Fes by IL-4
Woetmann et al., J Biol Chem 2003 : In contrast, IL-4 induced tyrosine phosphorylation of Janus kinase-1 and STAT6 is not affected, suggesting that PP2A acts downstream of Janus kinases in IL-4 signaling
Zhou et al., J Immunol 2003 : Thus, in humans, IL-4 alone is sufficient to drive AID expression, and CD40 signaling is required for optimal AID production ; IL-4 induced AID expression is mediated via the JAK/STAT signaling pathway, and can be negatively regulated by the JAK phosphatase activity of CD45
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Ratthé et al., J Leukoc Biol 2007 : We also demonstrated that IL-4 induced phosphorylation of Syk, p38, Erk-1/2, JNK, Jak-1 , Jak-2, STAT6, and STAT1 and that treatment of cells with the inhibitors piceatannol, SB203580, PD98059, or AG490 reversed the ability of IL-4 to delay neutrophil apoptosis
Cho et al., Mol Immunol 2011 : Although IL-4 induced tyrosine phosphorylation of JAK1 and TYK2, RNA interference experiments revealed that only JAK1 was responsible for the IL-4 stimulated STAT6 phosphorylation
Bhattacharjee et al., Free Radic Biol Med 2013 : Our data demonstrate that although the receptor associated tyrosine kinases Jak2 and Tyk2 are activated after the recruitment of IL-13 to its receptor ( containing IL-4Ra and IL-13Ra1 ), IL-4 stimulates Jak1 activation
Keegan et al., Proc Natl Acad Sci U S A 1995 : In this report we demonstrate that both IL-4 and IL-13 induced the tyrosine phosphorylation of 4PS and JAK1
Tortolani et al., J Immunol 1995 (Leukemia) : In addition, IL-4 and IL-7 induced the rapid tyrosine phosphorylation of JAK3 and JAK1, and IL-4 activated both JAK3 and JAK1 phosphotransferase activity
Malabarba et al., J Biol Chem 1995 : The present study suggests that JAK1 plays a subordinate role in IL4 receptor signaling, and that in certain cells exclusive JAK3 activation may mediate IL4 induced cell growth
Brunn et al., J Biol Chem 1995 : Both IL-2 and IL-4 stimulated the rapid activation of JAK1 and JAK3, whereas JAK2 activity was unaffected by either cytokine
Welham et al., J Biol Chem 1995 (Leukemia, Erythroblastic, Acute...) : Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1
Barber et al., Mol Cell Biol 1994 : In contrast, stimulation with IL-2 or the related cytokine IL-4 resulted in the rapid, dose dependent tyrosine phosphorylation of JAK1 and an additional 116-kDa protein ... Immune complex kinase assays confirmed that IL-2 and IL-4 activated JAK1 and EPO activated JAK2
Russell et al., Science 1994 (Severe Combined Immunodeficiency) : IL-2, IL-4 , IL-7 ( whose receptors are known to contain gamma c ), and IL-9 ( whose receptor is shown here to contain gamma c ) induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and Jak3
Murata et al., J Biol Chem 1995 (Colonic Neoplasms) : The phosphorylation of JAK1 and JAK2 was induced by IL-4 stimulation ; however, Tyk2 was constitutively phosphorylated, and IL-4 treatment further augmented this phosphorylation
Chuang et al., J Biochem 1996 (Carcinoma, Hepatocellular) : Interleukin 4 , but not insulin, stimulated the tyrosine phosphorylation of JAK1 and, to a lesser extent, JAK2
Oakes et al., Immunity 1996 (Severe Combined Immunodeficiency) : Although IL-2 induced phosphorylation of IL-2R beta, JAK1, and STAT5 all required the presence of JAK3, IL-4 mediated phosphorylation of JAK1 , STAT6, and insulin receptor substrates 1 and 2 did not
Wang et al., J Immunol 1997 (Fibrosarcoma) : It has been shown that IL-4 induces the tyrosine phosphorylation of JAK1 and JAK3 in the majority of hemopoietic cell types, and JAK2 and TYK2 in several other types
Chuang et al., Biochem Biophys Res Commun 1997 (Carcinoma, Hepatocellular) : In contrast, IL-4 stimulated tyrosine phosphorylation of JAK1 , JAK2 and tyk2 in this cell line ... In contrast, IL-4 stimulated tyrosine phosphorylation of JAK1, JAK2 and tyk2 in this cell line
Siemasko et al., J Immunol 1998 : The signal transduction pathway utilized by IL-4 to induce IgG1 involves tyrosine phosphorylation of the IL-4 receptor, JAK1 , JAK3, and STAT6 proteins induced by IL-4 binding to the IL-4R
Harada et al., Biochem Biophys Res Commun 1998 : Interleukin-4 (IL-4) has been shown to activate Janus kinase (Jak)-1 and Jak-3, followed by activation of STAT ( signal transducers and activators of transcription ) 6