◀ Back to IL4
IL4 — JAK1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
JAK1
→
IL4
(increases)
Doucet et al., Oncogene 2000*
Evidence: Tyrosine phosphorylation of JAK1 was detected at a very low concentration of IL-4 (1 ng/ml), while IL-13 induced phosphorylation only at concentrations of 50 ng/ml and above, both in normal (Figure 2a,b, upper blots) and tumor lung myo®broblasts (Figure 2c,d, upper blots).
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
SHC (SHC1)
(modification, activates)
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BioCarta il 4 signaling pathway:
IRS1/2/GRB2 complex (GRB2)
→
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IRS1/2/GRB2 complex (GRB2)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
GRB2
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
→
GRB2
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4 (IL4)
→
IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R)
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-4 (IL4)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, inhibits)
Kashiwada et al., J Immunol 2001, Hanson et al., J Biol Chem 2003, Chen et al., J Immunol 2004, Pernis et al., Proc Natl Acad Sci U S A 1995, Quelle et al., Mol Cell Biol 1995, Hou et al., Science 1994, Shimoda et al., Nature 1996, Haque et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database IL4-mediated signaling events:
BCL6 (BCL6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
(T-helper 2 cell differentiation, inhibits)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
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NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
STAT6 (dimer) complex (STAT6)
(T-helper 2 cell differentiation, activates)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
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NCI Pathway Database IL4-mediated signaling events:
ETS1 (ETS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Travagli et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
STAT6 (dimer) complex (STAT6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Travagli et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHP1 (PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHP1 (PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., J Immunol 2001, Wurster et al., Mol Cell Biol 2002, Sun et al., Nature 1995, Izuhara et al., Blood 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IRS1 (IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IRS1 (IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
SOCS1 (SOCS1)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL13RA1/JAK2 complex (IL13RA1-JAK2)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SOCS1 (SOCS1)
→
IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2)
(modification, inhibits)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2)
→
IL13RA1/JAK2 complex (IL13RA1-JAK2)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4 (IL4)
(modification, collaborate)
Kondo et al., Science 1993*, Russell et al., Science 1993*
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4R/JAK1 complex (IL4R-JAK1)
(modification, collaborate)
Kondo et al., Science 1993*, Russell et al., Science 1993*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4 (IL4)
→
IL4R/JAK1 complex (IL4R-JAK1)
(modification, collaborate)
Kondo et al., Science 1993*, Russell et al., Science 1993*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
(modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
IRS2 (IRS2)
(modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
IRS2 (IRS2)
(modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
SOCS5 (SOCS5)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SOCS5 (SOCS5)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, inhibits)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL2R gamma/JAK3 complex (IL2RG-JAK3)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2)
→
Dok-R (DOK2)
(modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
Dok-R (DOK2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
STAT6 (dimer) complex (STAT6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Sherman et al., J Immunol 1999
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2)
→
STAT6 (STAT6)
(modification, activates)
Hou et al., Science 1994, Murata et al., J Immunol 1996
Evidence: mutant phenotype
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
SOCS1 (SOCS1)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SOCS1 (SOCS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, inhibits)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL2R gamma/JAK3 complex (IL2RG-JAK3)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
STAT5 (STAT5A/STAT5B)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Mora et al., J Immunol 2001
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
FES (FES)
(modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
FES (FES)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
CD40LG (CD40LG)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(transcription, activates)
Gupta et al., J Exp Med 1999
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
→
SHC (SHC1)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHC (SHC1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Wery-Zennaro et al., FEBS Lett 1999
:
In this study, we report that in human B cells,
IL-4 caused rapid phosphorylation of
Janus kinase (JAK) 1 and JAK3 tyrosine kinases ... In keratinocytes,
IL-4 induced
JAK1 and JAK2 phosphorylation but, unlike in immune cells, IL-4 did not involve JAK3 activation for its signaling
Haque et al., J Biol Chem 2000
:
We show that the SH2 domains of SOCS-2, SOCS-3, and cytokine-inducible SH2 containing protein are functionally redundant in regulating the
IL-4 dependent
Jak-Stat signaling ... Thus, the Thr-Phe motif in the Pre-SH2 domain plays a critical role in SOCS-3 mediated inhibition of the
IL-4 dependent
Jak-Stat signaling, likely by regulating the mode of SOCS-Jak interaction
Jiang et al., J Immunol 2001
:
Examination of Jak1-deficient cell lines demonstrates that
Jak1 is
required for the activation of Fes by
IL-4
Woetmann et al., J Biol Chem 2003
:
In contrast,
IL-4 induced tyrosine phosphorylation of
Janus kinase-1 and STAT6 is not affected, suggesting that PP2A acts downstream of Janus kinases in IL-4 signaling
Zhou et al., J Immunol 2003
:
Thus, in humans,
IL-4 alone is sufficient to drive AID expression, and CD40 signaling is required for optimal AID production ; IL-4 induced AID expression is mediated via the JAK/STAT signaling pathway, and can be negatively
regulated by the
JAK phosphatase activity of CD45
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Ratthé et al., J Leukoc Biol 2007
:
We also demonstrated that
IL-4 induced phosphorylation of Syk, p38, Erk-1/2, JNK,
Jak-1 , Jak-2, STAT6, and STAT1 and that treatment of cells with the inhibitors piceatannol, SB203580, PD98059, or AG490 reversed the ability of IL-4 to delay neutrophil apoptosis
Cho et al., Mol Immunol 2011
:
Although
IL-4 induced tyrosine phosphorylation of
JAK1 and TYK2, RNA interference experiments revealed that only JAK1 was responsible for the IL-4 stimulated STAT6 phosphorylation
Bhattacharjee et al., Free Radic Biol Med 2013
:
Our data demonstrate that although the receptor associated tyrosine kinases Jak2 and Tyk2 are activated after the recruitment of IL-13 to its receptor ( containing IL-4Ra and IL-13Ra1 ),
IL-4 stimulates
Jak1 activation
Keegan et al., Proc Natl Acad Sci U S A 1995
:
In this report we demonstrate that both
IL-4 and IL-13
induced the tyrosine phosphorylation of 4PS and
JAK1
Tortolani et al., J Immunol 1995
(Leukemia) :
In addition,
IL-4 and IL-7 induced the rapid tyrosine phosphorylation of JAK3 and JAK1, and IL-4
activated both JAK3 and
JAK1 phosphotransferase activity
Malabarba et al., J Biol Chem 1995
:
The present study suggests that
JAK1 plays a subordinate role in
IL4 receptor signaling, and that in certain cells exclusive JAK3 activation may mediate IL4 induced cell growth
Brunn et al., J Biol Chem 1995
:
Both IL-2 and
IL-4 stimulated the rapid activation of
JAK1 and JAK3, whereas JAK2 activity was unaffected by either cytokine
Welham et al., J Biol Chem 1995
(Leukemia, Erythroblastic, Acute...) :
Both IL-13 and
IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and
Jak-1
Barber et al., Mol Cell Biol 1994
:
In contrast, stimulation with IL-2 or the related cytokine
IL-4 resulted in the rapid, dose dependent tyrosine phosphorylation of
JAK1 and an additional 116-kDa protein ... Immune complex kinase assays confirmed that IL-2 and
IL-4 activated
JAK1 and EPO activated JAK2
Russell et al., Science 1994
(Severe Combined Immunodeficiency) :
IL-2,
IL-4 , IL-7 ( whose receptors are known to contain gamma c ), and IL-9 ( whose receptor is shown here to contain gamma c )
induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases
Jak1 and Jak3
Murata et al., J Biol Chem 1995
(Colonic Neoplasms) :
The phosphorylation of
JAK1 and JAK2 was
induced by
IL-4 stimulation ; however, Tyk2 was constitutively phosphorylated, and IL-4 treatment further augmented this phosphorylation
Chuang et al., J Biochem 1996
(Carcinoma, Hepatocellular) :
Interleukin 4 , but not insulin,
stimulated the tyrosine phosphorylation of JAK1 and, to a lesser extent,
JAK2
Oakes et al., Immunity 1996
(Severe Combined Immunodeficiency) :
Although IL-2 induced phosphorylation of IL-2R beta, JAK1, and STAT5 all required the presence of JAK3,
IL-4 mediated phosphorylation of
JAK1 , STAT6, and insulin receptor substrates 1 and 2 did not
Wang et al., J Immunol 1997
(Fibrosarcoma) :
It has been shown that
IL-4 induces the tyrosine phosphorylation of
JAK1 and JAK3 in the majority of hemopoietic cell types, and JAK2 and TYK2 in several other types
Chuang et al., Biochem Biophys Res Commun 1997
(Carcinoma, Hepatocellular) :
In contrast,
IL-4 stimulated tyrosine phosphorylation of
JAK1 , JAK2 and tyk2 in this cell line ... In contrast,
IL-4 stimulated tyrosine phosphorylation of JAK1,
JAK2 and tyk2 in this cell line
Siemasko et al., J Immunol 1998
:
The signal transduction pathway utilized by IL-4 to induce IgG1 involves tyrosine phosphorylation of the IL-4 receptor,
JAK1 , JAK3, and STAT6 proteins
induced by
IL-4 binding to the IL-4R
Harada et al., Biochem Biophys Res Commun 1998
:
Interleukin-4 (IL-4) has been shown to
activate Janus kinase (Jak)-1 and Jak-3, followed by activation of STAT ( signal transducers and activators of transcription ) 6