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CCL2 — IL10

Text-mined interactions from Literome

Kolios et al., Eur J Immunol 1999 : In contrast, IL-10 had no effect on either MCP-1 , or RANTES, or IL-8 generation
Murao et al., FEBS Lett 1999 : In human vascular endothelial cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous monocyte chemoattractant protein-1 protein secretion, mRNA expression and promoter activity
Ishikawa et al., J Am Soc Nephrol 1999 : Bioflavonoid quercetin inhibits interleukin-1 induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB
Olszyna et al., J Infect Dis 2000 (Endotoxemia) : Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the effect of IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1
Akoum et al., J Clin Endocrinol Metab 2000 (Endometriosis) : Estradiol amplifies interleukin-1 induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis ... In the present study we report that estradiol ( E2 ) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1 induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid ( mRNA ) synthesis, whereas progesterone had no significant effects
Yamamoto et al., Biochem Biophys Res Commun 2001 (Scleroderma, Localized) : Our data indicate that IL-10 differentially regulates TGF-beta and MCP-1 in the modulation of ECM proteins and therefore suggest that IL-10 plays a role in the regulation of tissue remodeling
Yoshida et al., Invest Ophthalmol Vis Sci 2001 : IL-4 and -13, but not IL-10 , enhanced constitutive and TNF-alpha induced HRPE IL-8 and MCP-1 secretion ... IL-4 and -13 reduced monocyte IL-8 and MCP-1, whereas IL-10 reduced monocyte IL-8 but enhanced MCP-1 ... IL-8 secretion by HRPE cell-monocyte cocultures was inhibited by IL-4, -10, and -13, whereas MCP-1 was inhibited only by IL-10
Damås et al., Basic Res Cardiol 2001 : We hypothesised that MCP-1 may directly contribute to an inflammatory response in the cardiomyocytes, and in the present study we examined in adult rat cardiomyocytes : ( i ) the effect of tumour necrosis factor (TNF)alpha on MCP-1 production, ( ii ) the effect of MCP-1 on production of other inflammatory cytokines, and ( iii ) if the anti-inflammatory cytokine interleukin (IL)-10 could suppress any TNFalpha induced MCP- 1 production
Momoi et al., Chest 2001 (Adenocarcinoma...) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced endogenous MCP-1 protein secretion and messenger RNA expression
Omata et al., J Immunol 2002 : The production of IL-10 , a potent endogenous IL-12 inhibitor, was not affected by MCP-1
Ikeda et al., J Leukoc Biol 2002 : Interleukin-10 differently regulates monocyte chemoattractant protein-1 gene expression depending on the environment in a human monoblastic cell line, UG3 ... The enhancement of binding activity of nuclear factor Sp1 (Sp-1) and signal transducer and activators of transcription ( STAT ) 1 and 3 but not nuclear factor kappaB (NF-kappaB) was associated with this IL-10 induced MCP-1 expression ... The combination of activated Sp-1 and STATs is important for IL-10 induced MCP-1 expression in resting monocytes/macrophages, and the inhibition of LPS induced NF-kappaB binding is crucial for down-regulation of MCP-1 by IL-10 in stimulated monocytes/macrophages
Wright et al., J Clin Immunol 2003 (Osteomyelitis...) : We investigated the potential down-regulators of chemokine secretion IL-4, IL-10 , IL-13, dexamethasone, and PGE2, IL-10 and IL-13 down-regulate M. tuberculosis induced IL-8, IP-10, RANTES, and MCP-1 secretion from MG-63 cells by between 48 and 94 % ( P < 0.05 ) but do not inhibit chemokine gene transcription
Elhofy et al., J Leukoc Biol 2005 (Encephalomyelitis, Autoimmune, Experimental) : Overexpression of CCL2 in the CNS resulted in decreased interleukin-12 receptor expression by antigen-specific T cells
Musso et al., Int J Immunopathol Pharmacol 2005 : IL-10 enhances CCL2 release and chemotaxis induced by CCL16 in human monocytes ... IL-10 markedly increased CCL2 production induced by CCL16, but suppressed that of CXCL8
Gomes et al., Shock 2006 (Disease Models, Animal...) : These results indicate that endogenous MCP-1/CCL2 positively regulates IL-10 but negatively controls macrophage migration inhibitory factor during peritoneal sepsis, thus suggesting an important immunomodulatory role for MCP-1/CCL2 in controlling the balance between proinflammatory and anti-inflammatory factors in sepsis
Forsythe et al., Am J Respir Crit Care Med 2007 (Asthma...) : Oral treatment with live Lactobacillus reuteri but not Lactobacillus salivarius significantly attenuated the influx of eosinophils to the airway lumen and parenchyma and reduced the levels of tumor necrosis factor, monocyte chemoattractant protein-1 , IL-5, and IL-13 in bronchoalveolar lavage fluid of antigen challenged animals, but there was no change in eotaxin or IL-10
López et al., Endocrinology 2008 (Arthritis, Experimental...) : This compound has potent antiinflammatory activity in vivo and represses the transcription of the inflammatory cytokine monocyte chemoattractant protein-1 and induces the antiinflammatory cytokine IL-10
Yan et al., Dev Comp Immunol 2008 : Immunoregulin HA possibly unregulated the IL-10 production to inhibit IFN-gamma and MCP-1 secretion in the current experiments
Zhao et al., Comp Biochem Physiol B Biochem Mol Biol 2009 : In the current studies, Immunoregulin TP1 inhibited the IFN-gamma and MCP-1 secretion possibly by upregulating the IL-10 production, and finally might facilitate the blood feeding of this horsefly
Su et al., Clinical and vaccine immunology : CVI 2010 (Tuberculosis, Pulmonary) : The levels of expression of TNF-alpha, MCP-1 , IFN-gamma, and IL-1beta were decreased ; and the level of IL-10 increased in early responders
Takada et al., J Immunol 2010 (Colitis...) : MCP-1 deficiency caused impaired IL-10 production by LPMs and led to exacerbation of dextran sulfate sodium induced acute colitis ... Unlike LPM1, the LPM2 subset migrated in response to MCP-1 and produced a larger amount of IL-10 in response to commensal bacteria
Bosschaerts et al., PLoS Pathog 2010 (Trypanosomiasis) : Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2 , IFN-gamma and MyD88 signaling
Pattison et al., FEBS Lett 2013 : Furthermore we find that IL-10 knockout increases MCP-1 production in response to LPS, which may reflect an ability of IL-10 to repress IFNß production
Burel et al., Nucleic acid therapeutics 2013 : In mice, the alterations at 70 mg/kg/week included spleen weight increase up to 1.4-fold relative to control, increases in alanine aminotransferase and aspartate aminotransferase up to 1.8-fold over control, interleukin-10 increases up to 3.7-fold, and monocyte chemoattractant protein-1 increase up to 1.9-fold over control ... In mice, the alterations at 70 mg/kg/week included spleen weight increase up to 1.4-fold relative to control, increases in alanine aminotransferase and aspartate aminotransferase up to 1.8-fold over control, interleukin-10 increases up to 3.7-fold, and monocyte chemoattractant protein-1 increase up to 1.9-fold over control
Goppelt-Struebe et al., FEBS Lett 1995 : Synergistic induction of monocyte chemoattractant protein-1 ( MCP-1 ) by platelet derived growth factor and interleukin-1
Hayashi et al., J Neuroimmunol 1995 : Lipopolysaccharide (LPS), interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induced MCP-1 secretion by astrocytes, but not microglia
Seitz et al., Eur J Immunol 1995 : IL-10 stimulated sTNF-R p55 dose-dependently and inhibited MCP-1 release from IL-1 beta activated fibroblasts, whereas IL-8 production was not affected
Colotta et al., Am J Pathol 1994 : Induction of MCP-1 transcript by thrombin was not reduced by blocking interleukin-1 and tumor necrosis factor, suggesting that these mediators are not involved in thrombin induced expression of MCP-1
Yano et al., J Immunol 1996 : In contrast, IL-10, but neither IL-4 nor IL-13, induced unstimulated peripheral blood monocytes to produce biologically active MCP-1 protein within 4 h, reaching a maximal level at 12 h. IL-10 induced MCP-1 production was reduced by pretreatment of IL-10 with anti-IL-10 Ab, negating the involvement of contaminated endotoxin ... Moreover, IL-10 induced MCP-1 mRNA expression in unstimulated monocytes, independent of de novo protein synthesis ... These findings suggest that IL-10 regulates MCP-1 production by monocytes/macrophages in a different way from other Th2 cytokines, such as IL-4 and IL-13, and contributes to host defense responses
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Boorstein et al., Curr Eye Res 1997 : Effects of IL-10 on IL-1 beta ( 0.2 or 2 ng/ml ) -, or TNF-alpha ( 0.2 or 2 ng/ml ) -induced IL-8 and MCP-1 secretion and gene expression were assessed using enzyme linked immunosorbent assay ( ELISA ) and Northern blot analysis ... IL-10 alone did not induce MCP-1 or IL-8 secretion or steady-state mRNA expression, nor modulate IL-1 beta-, TNF-alpha- or IFN-gamma induced IL-8 or MCP-1
Jordan et al., Br J Pharmacol 1997 : IL-13, but not IL-10 , significantly enhanced IL-8 and MCP-1 release in response to IL-1alpha or TNFalpha