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ANGPT2 — SMAD1
Text-mined interactions from Literome
Mima et al., Lab Invest 2006
(Diabetes Mellitus, Experimental...) :
Here we examined the
effect of
Ang II on the expression of
Smad1 and mesangial matrix expansion in streptozotocin (STZ) induced diabetic rats in vivo, using Ang II type 1 receptor blocker, olmesartan ...
Ang II induced Col4 synthesis and increased expression of phospho-Src and
phospho-Smad1 in cultured mesangial cells, which was blocked by olmesartan
Zhang et al., Hypertension 2010
(Fibrosis...) :
Enhanced upregulation of the
Ang II type I receptor and
activation of the transforming growth
factor-beta/Smad and nuclear factor-kappaB signaling pathways may be the mechanisms by which CRP promotes cardiac fibrosis and inflammation under high Ang II conditions