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CHUK — TANK

Pathways - manually collected, often from reviews:

• WikiPathways Structural Pathway of Interleukin 1 (IL-1): CHUK → TANK (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: TANK — CHUK (coimmunoprecipitation) Chariot et al., J Biol Chem 2002
• IRef Biogrid Interaction: CHUK — TANK (physical association, affinity chromatography technology) Chariot et al., J Biol Chem 2002
• IRef Hprd Interaction: CHUK — TANK (in vivo) Chariot et al., J Biol Chem 2002

Text-mined interactions from Literome

Devin et al., Immunity 2000 : The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1 : TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
Habelhah et al., EMBO J 2004 : Inhibition of Ubc13 expression by RNAi resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of IKK or p38
Zhang et al., J Mol Biol 2009 : TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells ... Thus, our data demonstrate that TRAF2 negatively regulates basal IKK activity in resting cells and inhibits TNFalpha induced cell death by recruiting anti-apoptotic proteins to the TNFR1 complex rather than by activating the NF-kappaB pathway
Zhang et al., J Mol Biol 2010 : Here, we report that stable expression of TRAF2-DeltaR at a physiological level in TRAF2 and TRAF5 double knockout ( TRAF2/5 DKO ) cells almost completely restores normal TNFalpha induced IKK activation, but not RIP1 polyubiquitination