Gene interactions and pathways from curated databases and text-mining

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CASP1 — IFT57

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CASP1 → IFT57 (increases)
    Evidence: Nuclear fragmentation, caspase-1, caspase-8, caspase-9/caspase-6 and caspase-3 activation were increased significantly in Hippi expressing cells. Cleavage of Bid, release of cytochrome c and apoptosis inducing factor (AIF) from mitochondria were also increased in GFP-Hippi expressing cells.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *