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INS — WNT2
Text-mined interactions from Literome
Liu et al., Adv Exp Med Biol 2010
(Diabetes Mellitus, Type 2) :
Beta-catenin/TCF7L2 dependent
Wnt signaling ( the canonical pathway ) is
involved in pancreas development, islet function, and
insulin production and secretion
Yoon et al., Genes Dev 2010
:
Wnt signaling
regulates mitochondrial physiology and
insulin sensitivity
Palsgaard et al., J Biol Chem 2012
(MAP Kinase Signaling System...) :
We find that
Wnt stimulation
leads to phosphorylation of
insulin signaling key mediators, including Akt, GSK3ß, and ERK1/2, although with a lower fold stimulation and slower time course than observed for insulin