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CDKN2B — SMAD2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Feng et al., EMBO J 2000
:
Interference with, or deficiency in,
Smad2 , Smad3 or Smad4 functions also
reduced or abolished the TGF-beta dependent p15(Ink4B) induction, whereas the absence of Sp1 reduced the basal and TGF-beta induced
p15(Ink4B) transcription
Feng et al., Mol Cell 2002
:
Direct interaction of c-Myc with
Smad2 and Smad3 to
inhibit TGF-beta mediated induction of the CDK inhibitor
p15(Ink4B) ... Through its direct interaction with Smads, c-Myc binds to the Sp1-Smad complex on the promoter of the p15(Ink4B) gene, thereby inhibiting the TGF-beta induced transcriptional activity of Sp1 and
Smad/Sp1 dependent transcription of the
p15(Ink4B) gene
Gomis et al., Cancer Cell 2006
(Breast Neoplasms...) :
We found the transcription factor C/EBPbeta to be essential for TGFbeta induction of the cell cycle inhibitor
p15INK4b by a FoxO-Smad complex and
repression of c-MYC by an
E2F4/5-Smad complex in human epithelial cells