Gene interactions and pathways from curated databases and text-mining

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IL1A — SLPI

Text-mined interactions from Literome

Nikawa et al., Am J Physiol Gastrointest Liver Physiol 2001 : In contrast, IL-1beta markedly increased the activity, protein, and mRNA of the bone-type ALP only when RA was present
Takeshita et al., J Periodontal Res 1992 : On the other hand, IL-1 beta significantly inhibited alkaline phosphatase (ALP) activity of the cells in a dose dependent manner
Min et al., J Endod 2006 : IL-1alpha induces ALP , ON, and OC in tooth mineralization and it may play a role in the cytoprotection of pulp cells via HO-1 expression, while long-term treatment of TNF-alpha may inhibit the tooth mineralization
Nokhbehsaim et al., J Orofac Orthop 2010 (Mechanotransduction, Cellular...) : In general, CTS also downregulated the IL1ß induced COL1, ALP , and RUNX2 expression
Hah et al., Mol Biol Rep 2013 : TNF-a and IL-1ß enhanced the alkaline phosphatase (ALP) activity and alizarin red S staining in cultured human periosteal derived cells ... The functional role of TNF-a and IL-1ß in increasing the ALP activity and mineralization of periosteal derived cells primarily depends on the JNK signaling among the MAPK pathways
Nakase et al., Bone 1997 : The modulatory effects of interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha on bone morphogenetic protein (BMP)-2- and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells
Kanematsu et al., J Bone Miner Res 1997 : IL-1 alpha and TNF-alpha inhibited alkaline phosphatase (ALP) activity, which was significantly reversed by AG