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IDO1 — IL1B
Text-mined interactions from Literome
Fieren et al., Immunol Lett 1992
(Peritonitis) :
In view of the interregulatory effects between PGE2 and macrophage cytokines ( IL-1 beta and TNF alpha ) in their production, we examined in the present work to what extent the LPS induced release of either
IL-1 beta or TNF alpha in vitro from CAPD originated peritoneal macrophages is
affected by graded doses of exogenous PGE2 ( range 0-1000 ng/ml ) and by the cyclooxygenase inhibitor
indomethacin (INDO) ( 10 ( -6 ) M )
Spalletta et al., Mol Psychiatry 2006
(Brain Ischemia...) :
The increased production of proinflammatory cytokines such as
IL-1beta , TNF-alpha or IL-18 resulting from stroke may
lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of
indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia
Shirey et al., Infect Immun 2006
:
Gamma interferon ( IFN-gamma ) -induced
indoleamine dioxygenase (IDO) , which inhibits chlamydial replication by reducing the availability of tryptophan, is
up-regulated by
interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha)