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GZMB — IL2

Text-mined interactions from Literome

Spitzer et al., Cell Immunol 1999 (Body Weight) : In contrast, granzyme B protein expression and enzymatic activity increased in response to interleukin 2
Malek et al., J Immunol 2001 : IL-2 is required for these functions in part by regulation of cyclin D3 and granzyme B
Zhou et al., Toxicological sciences : an official journal of the Society of Toxicology 2003 : Semiquantitative RT-PCR and real-time PCR analyses indicated that EtOH consumption inhibits the induction of perforin, granzyme A, and granzyme B in response to IL-2 ... Pyrrolidine dithiocarbamate ( PDTC ) and N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2 stimulated NK cells in an EMSA and also inhibited the IL-2 induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells
Janas et al., J Immunol 2005 : We show in this study that IL-2 increased the expression of perforin and granzyme A, B, and C mRNA ; intracellular granzyme B protein levels ; and cytolytic function in a dose dependent manner during primary activation of murine CD8+ T cells in vitro ... This property of bcl-2 transgenic T cells also allowed the demonstration that induction of granzyme A, B, and C mRNA and granzyme B protein required exogenous IL-2 , whereas induction of perforin and IFN-gamma expression did not
Tamang et al., Cytokine 2006 : Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens : multiclonal responses that are extremely lytic if triggered and short lived after cytokine withdrawal ... To our surprise, both IL-2 and IL-15 induced not only proliferation, but also profound granzyme B and lytic capacity from CD8+ T cells in the absence of antigen or TCR-stimulation
Ferran et al., Clin Exp Immunol 1991 : 145-2C11 induced significant release of TNF and IL-2 in all four strains
Iwabuchi et al., J Immunol 1991 : However, no significant difference in proliferative responses to 2C11 plus PMA, in influx of Ca2+ after stimulation with 2C11 or IL-2 production in response to 2C11 plus PMA or PMA plus A23187 was demonstrated between C3H and AKR recipient chimeras
Zhang et al., Int Immunopharmacol 2008 : The protein levels of GZM-B and cytotoxicity of NK-92 cells in response to IL-2 or IFNalpha were analyzed, the results showed a positive relationship between cytotoxicity and GZM-B expression level
Brown et al., Cell Immunol 2009 : At low peptide concentration, exogenous IL-2 was necessary to drive granzyme B (GrB) expression and perforin mediated lysis
Aste-Amezaga et al., Cell Immunol 1994 : IL-12 induction of perforin mRNA accumulation was not synergistic with either IL-2 or anti-CD16 stimulation, whereas granzyme B mRNA accumulation, induced by IL-2 or anti-CD16 stimulation, was slightly potentiated by IL-12
Makrigiannis et al., J Immunol 1997 : Since RAP is known to block IL-2 signaling through the IL-2R, we hypothesized that RAP may interfere with CTL generation by inhibiting IL-2 induced expression of granzyme (Gzm) B , perforin, and/or Fas ligand (FasL)
Gardiner et al., Blood 1998 : Interleukin-2 (IL-2) induced significant granzyme B activity in cord cells in contrast to BM cells, in which very little activity was measured ... Western blotting confirmed these findings, with IL-2 inducing granzyme B protein expression in cord cells but not detectable levels in BM cells